Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.45 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.45 |
| ▸ | ITGAV | P06756 | 2/20 | 0.45 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7378959 | 0.84 | ITGB3 (0.64) | KMT2AMEN1NPC1HTTMAPT | |
| SCHEMBL7373424 | 0.82 | ITGB3 (0.64) | KMT2AMEN1SMN1; SMN2ITGB3ITGA2B | |
| SCHEMBL7457481 | 0.81 | NR1H4 (0.67) | KMT2AMEN1ITGB3ITGA2BITGB1 | |
| SCHEMBL7377737 | 0.79 | KMT2A (0.50) | KMT2AMEN1NPC1HTTMAPT | |
| SCHEMBL7380126 | 0.78 | ITGB3 (0.53) | KMT2AMEN1NPC1SMN1; SMN2ITGB3 | |
| SCHEMBL7503150 | 0.78 | KMT2A (0.50) | KMT2AMEN1NPC1SMN1; SMN2ITGB3 | |
| SCHEMBL7861974 | 0.78 | ITGB3 (0.64) | SMN1; SMN2ITGB3ITGA2BITGB1ITGAV | |
| SCHEMBL7449520 | 0.77 | GAA (0.47) | KMT2AMEN1NPC1MAPTITGB3 | |
| SCHEMBL7378119 | 0.77 | MEN1 (0.47) | KMT2AMEN1SMN1; SMN2ITGB3ITGA2B | |
| SCHEMBL7372911 | 0.77 | ITGB3 (0.54) | NPC1SMN1; SMN2ITGB3ITGA2BITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251944-B1 | (VITRONECTIN RECEPTOR) INTEGRIN ANTAGONIST, USEFUL FOR TREATING ANGIOGENESIS, TUMOR GROWTH, TUMOR METASTASIS, OSTEOPOROSIS AND HUMORAL HYPERCALCEMIA OF MALIGNANCY | G. D. SEARLE & COMPANY | 2001-06-26 | — | — | US | claimed |