Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | ACP3 | P15309 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27553469 | 1.00 | AKR1C3 (0.43) | AKR1C3AKR1C2L3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL7780324 | 0.85 | CRHBP (0.47) | AKR1C3AKR1C2L3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL27533527 | 0.80 | MEN1 (0.40) | AKR1C3AKR1C2L3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL7780359 | 0.80 | MAPT (0.41) | AKR1C3AKR1C2L3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL7787532 | 0.80 | MEN1 (0.40) | AKR1C3AKR1C2L3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL7780398 | 0.79 | TDP1 (0.46) | AKR1C3AKR1C2L3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL7780395 | 0.79 | MEN1 (0.42) | ALDH1A1MEN1KMT2ASLC6A9SLC6A2 | |
| SCHEMBL7785688 | 0.78 | CRHBP (0.44) | AKR1C3AKR1C2L3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL7785576 | 0.78 | CRHBP (0.44) | AKR1C3AKR1C2L3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL7785105 | 0.78 | CRHBP (0.44) | AKR1C3AKR1C2L3MBTL1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |