Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.61 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7785364 | 0.93 | ADRA2A (0.71) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL7788877 | 0.92 | HTR1A (0.51) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8126954 | 0.91 | HTR1A (0.52) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8128165 | 0.90 | HTR1A (0.54) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL7788878 | 0.87 | HTR1A (0.65) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL7787377 | 0.87 | HTR1A (0.56) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL7785359 | 0.87 | HTR1A (0.53) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL7787370 | 0.86 | HTR1A (0.64) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL7780284 | 0.85 | ADRA2A (0.59) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL7787391 | 0.85 | HTR1A (0.66) | ADRA2AADRA2BADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251908-B1 | Piperazine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2001-06-26 | — | — | US | disclosed |