Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 15/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8608329 | 0.83 | CYP11B1 (0.39) | SIRT2ENPP2CYP11B1CYP11B2 | |
| SCHEMBL7787709 | 0.78 | CYP11B1 (0.37) | SIRT2ENPP2CYP11B1CYP11B2 | |
| SCHEMBL7784539 | 0.76 | CYP11B1 (0.40) | SIRT2ENPP2CYP11B1CYP11B2 | |
| SCHEMBL15487989 | 0.76 | CYP11B1 (0.40) | SIRT2ENPP2CYP11B1CYP11B2 | |
| SCHEMBL7787713 | 0.75 | CYP11B1 (0.37) | SIRT2ENPP2CYP11B1CYP11B2 | |
| SCHEMBL7786406 | 0.73 | CYP11B1 (0.40) | SIRT2ENPP2CYP11B1CYP11B2 | |
| Formic Acid SCHEMBL7797545 | 0.72 | SIRT2 (0.37) | SIRT2ENPP2CYP11B1CYP11B2 | |
| SCHEMBL7786397 | 0.72 | CYP11B1 (0.39) | SIRT2ENPP2CYP11B1CYP11B2 | |
| SCHEMBL28422181 | 0.71 | ADA (0.47) | SIRT2ENPP2CYP11B1CYP11B2 | |
| SCHEMBL26643915 | 0.71 | SIRT2 (0.35) | SIRT2ENPP2CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837679-B1 | 2-(1H-4(5)-IMIDAZOYL) CYCLOPROPYL DERIVATIVES | GLIATECH INC (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6008240-A | AN ANTAGONIST OF HISTAMINE H3 RECEPTORS; FOR TREATING ALLERGY, INFLAMMATION, CARDIOVASCULAR DISEASE (HYPER OR HYPOTENSION), GASTROINTESTINAL DISORDERS, CNS DISORDERS INVOLVING ATTENTION OR COGNITIVE DISORDERS | GLIATECH, INC. (US) | 1999-12-28 | — | — | US | disclosed |
| US-5990317-A | HISTAMINE H3 RECEPTOR ANTAGONIST FOR TREATING CNS DISORDERS INVOLVING ATTENTION OR COGNITIVE DISORDERS | GLIATECH, INC. (US) | 1999-11-23 | — | — | US | disclosed |