Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4097943 | 0.86 | KMT2A (0.53) | KMT2AMEN1ALDH1A1GLATSHR | |
| SCHEMBL11842165 | 0.81 | ALDH1A1 (0.55) | KMT2AMEN1ALDH1A1GLATSHR | |
| SCHEMBL8400925 | 0.80 | ALDH1A1 (0.53) | KMT2AMEN1ALDH1A1GLATSHR | |
| SCHEMBL4304223 | 0.79 | MEN1 (1.00) | KMT2AMEN1ALDH1A1GLATSHR | |
| SCHEMBL18762979 | 0.77 | MEN1 (0.57) | KMT2AMEN1ALDH1A1GLATSHR | |
| SCHEMBL6721398 | 0.77 | SIGMAR1 (0.47) | KMT2AMEN1ALDH1A1HPGDMAPT | |
| SCHEMBL27042408 | 0.76 | MEN1 (0.71) | KMT2AMEN1ALDH1A1GLATSHR | |
| SCHEMBL7528801 | 0.76 | HSD17B10 (0.40) | KMT2AMEN1ALDH1A1TSHRKDM4E | |
| SCHEMBL9113008 | 0.76 | HTT (0.49) | KMT2AMEN1ALDH1A1L3MBTL1MAPT | |
| SCHEMBL109209 | 0.75 | ALDH1A1 (0.43) | KMT2AMEN1ALDH1A1TSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251948-B1 | Tri-and tetra-substituted guanidines and their use as excitatory amino acid antagonists | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY AND THE UNIVERSITY OF OREGON | 2001-06-26 | — | — | US | claimed |