SCHEMBL7787992

SCHEMBL7787992

FC(F)C(F)(F)CC=Cc1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 3/20 0.43
IDO1 P14902 2/20 0.41
PAM P19021 1/20 0.41
S1PR4 O95977 1/20 0.40
ALDH1A1 P00352 1/20 0.40
LMNA P02545 1/20 0.40
MAPT P10636 1/20 0.40
S1PR1 P21453 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
MAOB P27338 2/20 0.38
NFE2L2 Q16236 1/20 0.38
PTPRC P08575 1/20 0.36
PTPN1 P18031 1/20 0.36
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
SIGMAR1 Q99720 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7788776 0.85 HTR2A (0.41) HTR2AIDO1PAMS1PR4ALDH1A1
SCHEMBL7783039 0.81 ALDH1A1 (0.44) HTR2AIDO1PAMS1PR4ALDH1A1
SCHEMBL31414061 0.81 IDO1 (0.48) HTR2AIDO1PAMALDH1A1LMNA
SCHEMBL7792765 0.81 IDO1 (0.48) HTR2AIDO1PAMALDH1A1LMNA
SCHEMBL7790769 0.79 LMNA (0.43) HTR2AIDO1PAMS1PR4ALDH1A1
SCHEMBL7791511 0.73 IDO1 (0.41) HTR2AIDO1PAMS1PR4ALDH1A1
SCHEMBL7792774 0.72 IDO1 (0.40) HTR2AIDO1PAMS1PR4ALDH1A1
SCHEMBL10338475 0.72 IDO1 (0.44) HTR2AIDO1PAMS1PR4ALDH1A1
SCHEMBL10338474 0.72 IDO1 (0.44) HTR2AIDO1PAMS1PR4ALDH1A1
SCHEMBL23919129 0.71 HTR2A (0.48) HTR2AIDO1PAMALDH1A1MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0890636-B1 Culture vessel MENICON CO LTD (JP) 2001-10-31 EP disclosed
US-6018001-A ACID TREATMENT OF A CONTACT LENS WHICH IS A COPOLYMER OF ASUGAR KETAL-CONTAINING (METH)ACRYLATE AND A SUGAR GLYCEROL KETAL-CONTAINING (METH)ACRYLATE AND A CO-MONOMER CONTAINING SILICON AND FLUORINE-MONOMER; OXYGEN PERMEABILITY MENICON CO., LTD. (JP) 2000-01-25 US disclosed
EP-0892297-A1 PROCESS FOR PRODUCING CONTACT LENS WITH HYDROPHILIC SURFACE AND CONTACT LENS OBTAINED THEREBY MENICON CO., LTD. (JP) 1999-01-20 EP disclosed
EP-0890636-A1 Culture vessel Menicon Co., Ltd. (JP) 1999-01-13 EP disclosed