Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 2/20 | 0.51 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.51 |
| ▸ | CTSK | P43235 | 12/20 | 0.48 |
| ▸ | CTSS | P25774 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7781128 | 0.90 | GRIK1 (0.49) | GRIK1GRIK2CTSKCTSSMEN1 | |
| SCHEMBL7788178 | 0.85 | CTSK (0.55) | GRIK1GRIK2CTSKCTSSMEN1 | |
| SCHEMBL7788744 | 0.85 | CTSK (0.55) | GRIK1GRIK2CTSKCTSSMEN1 | |
| SCHEMBL28752529 | 0.81 | CTSS (0.56) | CTSKCTSSCTSLCTSB | |
| SCHEMBL29063337 | 0.81 | CTSS (0.56) | CTSKCTSSCTSLCTSB | |
| SCHEMBL16343550 | 0.81 | CTSK (0.46) | GRIK1GRIK2CTSKCTSSMEN1 | |
| SCHEMBL29046818 | 0.81 | CTSS (0.56) | CTSKCTSSCTSLCTSB | |
| SCHEMBL7785602 | 0.81 | CTSK (0.46) | GRIK1GRIK2CTSKCTSSMEN1 | |
| SCHEMBL16343552 | 0.81 | CTSK (0.46) | GRIK1GRIK2CTSKCTSSMEN1 | |
| SCHEMBL5154499 | 0.81 | PPARA (0.39) | CTSKCTSSMEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0826663-B1 | Alkynylamino acid derivatives and their use as pharmaceutical compounds | LILLY CO ELI (GB) | 2001-10-31 | — | — | EP | disclosed |
| EP-0826663-A2 | Alkynylamino acid derivatives and their use as pharmaceutical compounds | ELI LILLY AND COMPANY LIMITED (GB) | 1998-03-04 | — | — | EP | disclosed |