Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.46 |
| ▸ | ACP3 | P15309 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7780673 | 1.00 | MAPKAPK2 (0.46) | MAPKAPK2ACP3KMT2AMEN1POLB | |
| Hydrochloric Acid SCHEMBL7787875 | 0.97 | MEN1 (0.45) | MAPKAPK2ACP3KMT2AMEN1POLB | |
| Hydrochloric Acid SCHEMBL7785581 | 0.93 | MEN1 (0.42) | MAPKAPK2ACP3KMT2AMEN1POLB | |
| Hydrochloric Acid SCHEMBL7785142 | 0.92 | KMT2A (0.44) | MAPKAPK2ACP3KMT2AMEN1POLB | |
| SCHEMBL7787895 | 0.92 | MEN1 (0.41) | MAPKAPK2ACP3KMT2AMEN1POLB | |
| Hydrochloric Acid SCHEMBL7780320 | 0.92 | POLB (0.48) | MAPKAPK2ACP3KMT2AMEN1POLB | |
| SCHEMBL7785092 | 0.91 | MAPKAPK2 (0.45) | MAPKAPK2GSK3BCYP3A4 | |
| SCHEMBL7789354 | 0.91 | MAPKAPK2 (0.45) | MAPKAPK2GSK3BCYP3A4 | |
| SCHEMBL7785088 | 0.90 | ALDH1A1 (0.41) | MAPKAPK2ACP3KMT2AMEN1POLB | |
| SCHEMBL7789345 | 0.90 | ALDH1A1 (0.46) | MAPKAPK2ACP3KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | claimed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | claimed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |