Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | POLB | P06746 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9038287 | 0.86 | KDM4E (0.49) | ALDH1A1KDM4EPOLBSMN1; SMN2LMNA | |
| SCHEMBL8124652 | 0.85 | KDM4E (0.51) | ALDH1A1KDM4EPOLBSMN1; SMN2LMNA | |
| SCHEMBL8125129 | 0.74 | ALDH1A1 (0.47) | ALDH1A1KDM4EPOLBSMN1; SMN2LMNA | |
| SCHEMBL5090716 | 0.71 | ALDH1A1 (0.47) | ALDH1A1KDM4EPOLBSMN1; SMN2LMNA | |
| SCHEMBL22911107 | 0.71 | ALDH1A1 (0.47) | ALDH1A1KDM4EPOLBSMN1; SMN2LMNA | |
| SCHEMBL5617361 | 0.71 | ALDH1A1 (0.47) | ALDH1A1KDM4EPOLBSMN1; SMN2LMNA | |
| SCHEMBL6468861 | 0.71 | ALDH1A1 (0.47) | ALDH1A1KDM4EPOLBSMN1; SMN2LMNA | |
| SCHEMBL7789860 | 0.70 | ALDH1A1 (0.41) | ALDH1A1KDM4EPOLBSMN1; SMN2LMNA | |
| SCHEMBL7552061 | 0.70 | ALDH1A1 (0.44) | ALDH1A1KDM4EPOLBSMN1; SMN2LMNA | |
| SCHEMBL6619139 | 0.70 | ALDH1A1 (0.50) | ALDH1A1KDM4EPOLBSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161243-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING A PYRIMIDINE DERIVATIVE AND CYCLODEXTRIN | Knoll GmbH (DE) | 2001-12-12 | — | — | EP | claimed |
| WO-2000056336-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING A PYRIMIDINE DERIVATIVE AND CYCLODEXTRIN | KNOLL GMBH (DE) | 2000-09-28 | — | — | WO | claimed |
| EP-0723546-B1 | 1,2,4 - TRIZOLO[1,5-a]PYRIMIDINE AND THEIR USE FOR TREATMENT OF NEUROLOGICAL DISORDERS | KNOLL AG (DE) | 2000-01-19 | — | — | EP | claimed |
| US-5753665-A | TRIAZOLOPYRIMIDINES, NERVOUS SYSTEM DISORDERS | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-05-19 | — | — | US | claimed |
| CN-1135754-A | Therapeutic agents | KNOLL AG (DE) | 1996-11-13 | — | — | CN | claimed |
| EP-0723546-A1 | 1,2,4 - Triazolo (1,5-a) pyrimitives and their use for treatment of neurological disorders | Knoll AG (DE) | 1996-07-31 | — | — | EP | claimed |
| WO-1995010521-A1 | THERAPEUTIC AGENTS | KNOLL AG (DE) | 1995-04-20 | — | — | WO | claimed |
| EP-1161243-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING A PYRIMIDINE DERIVATIVE AND CYCLODEXTRIN | Knoll GmbH (DE) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000056336-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING A PYRIMIDINE DERIVATIVE AND CYCLODEXTRIN | KNOLL GMBH (DE) | 2000-09-28 | — | — | WO | disclosed |
| EP-0723546-B1 | 1,2,4 - TRIZOLO[1,5-a]PYRIMIDINE AND THEIR USE FOR TREATMENT OF NEUROLOGICAL DISORDERS | KNOLL AG (DE) | 2000-01-19 | — | — | EP | disclosed |
| US-5753665-A | TRIAZOLOPYRIMIDINES, NERVOUS SYSTEM DISORDERS | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-05-19 | — | — | US | disclosed |
| CN-1135754-A | Therapeutic agents | KNOLL AG (DE) | 1996-11-13 | — | — | CN | disclosed |
| EP-0723546-A1 | 1,2,4 - Triazolo (1,5-a) pyrimitives and their use for treatment of neurological disorders | Knoll AG (DE) | 1996-07-31 | — | — | EP | disclosed |
| EP-0696593-A2 | Inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-02-14 | — | — | EP | disclosed |
| WO-1995010521-A1 | THERAPEUTIC AGENTS | KNOLL AG (DE) | 1995-04-20 | — | — | WO | disclosed |