Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9038287 | 0.93 | KDM4E (0.49) | KDM4EGAAGLAKCNH2ALDH1A1 | |
| SCHEMBL7789852 | 0.85 | ALDH1A1 (0.49) | KDM4EGAAGLAALDH1A1SMN1; SMN2 | |
| SCHEMBL9042210 | 0.76 | KDM4E (0.46) | KDM4EGAAGLAALDH1A1SMN1; SMN2 | |
| SCHEMBL9040174 | 0.74 | L3MBTL1 (0.49) | KDM4EGAAGLAALDH1A1SMN1; SMN2 | |
| SCHEMBL854288 | 0.74 | ALDH1A1 (0.42) | KDM4EGAAGLAALDH1A1SMN1; SMN2 | |
| SCHEMBL8125129 | 0.71 | ALDH1A1 (0.47) | KDM4EGAAGLAALDH1A1SMN1; SMN2 | |
| SCHEMBL5617361 | 0.68 | ALDH1A1 (0.47) | KDM4EGAAGLAALDH1A1SMN1; SMN2 | |
| SCHEMBL5090716 | 0.68 | ALDH1A1 (0.47) | KDM4EGAAGLAALDH1A1SMN1; SMN2 | |
| SCHEMBL7789860 | 0.68 | ALDH1A1 (0.41) | KDM4EGAAGLAALDH1A1SMN1; SMN2 | |
| SCHEMBL6619139 | 0.68 | ALDH1A1 (0.50) | KDM4EGAAGLAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723546-B1 | 1,2,4 - TRIZOLO[1,5-a]PYRIMIDINE AND THEIR USE FOR TREATMENT OF NEUROLOGICAL DISORDERS | KNOLL AG (DE) | 2000-01-19 | — | — | EP | disclosed |
| CN-1135754-A | Therapeutic agents | KNOLL AG (DE) | 1996-11-13 | — | — | CN | disclosed |