Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.57 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.49 |
| ▸ | DHODH | Q02127 | 2/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19212236 | 0.80 | NR1H2 (0.49) | ALDH1A1KDM4E | |
| SCHEMBL6608225 | 0.76 | CHRNB2 (0.59) | CHRNB2CHRNA4DHODHCHRNA7GBA1 | |
| SCHEMBL10987362 | 0.76 | CHRNB2 (0.59) | CHRNB2CHRNA4DHODHCHRNA7GBA1 | |
| SCHEMBL6413923 | 0.76 | CHRNB2 (0.46) | CHRNB2CHRNA4CYP3A4CHRNA7ALDH1A1 | |
| SCHEMBL22928701 | 0.76 | CHRNB2 (0.75) | CHRNB2CHRNA4CHRNA7ALDH1A1RIPK1 | |
| SCHEMBL12888668 | 0.75 | CHRNB2 (0.67) | CHRNB2CHRNA4CHRNA7GBA1ALDH1A1 | |
| SCHEMBL30632262 | 0.74 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNA7ALDH1A1RIPK1 | |
| SCHEMBL3460939 | 0.74 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNA7ALDH1A1RIPK1 | |
| SCHEMBL10028665 | 0.74 | CHRNB2 (0.85) | CHRNB2CHRNA4CHRNA7ALDH1A1RIPK1 | |
| SCHEMBL2227055 | 0.73 | CHRNB2 (0.55) | CHRNB2CHRNA4CHRNA7GBA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150963-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Aventis Pharma Deutschland GmbH (DE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046214-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-08-10 | — | — | WO | disclosed |