SCHEMBL7790085

SCHEMBL7790085

N#Cc1ccc(NC2CCC(O)CC2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 1/20 0.47
EPHX1 P07099 1/20 0.45
CCR6 P51684 1/20 0.44
JAK2 O60674 1/20 0.44
JAK1 P23458 1/20 0.44
TYK2 P29597 1/20 0.44
JAK3 P52333 1/20 0.44
CTSS P25774 1/20 0.43
CTSK P43235 1/20 0.43
CCNK O75909 1/20 0.43
CCNA2 P20248 1/20 0.43
CDK2 P24941 1/20 0.43
CDK12 Q9NYV4 1/20 0.43
DPP4 P27487 2/20 0.41
PIM1 P11309 1/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
SCN9A Q15858 1/20 0.40
MLNR O43193 2/20 0.39
CHUK O15111 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12733191 0.91 CCR6 (0.49) TRPA1EPHX1CCR6JAK2JAK1
SCHEMBL3475103 0.83 CTSK (0.57) TRPA1EPHX1CCR6CTSSCTSK
SCHEMBL15739641 0.83 CTSK (0.54) TRPA1EPHX1CCR6JAK2JAK1
SCHEMBL3816119 0.82 IRAK4 (0.51) TRPA1EPHX1CCR6JAK2JAK1
SCHEMBL13450562 0.82 CCR6 (0.47) TRPA1EPHX1CCR6JAK2JAK1
SCHEMBL16480090 0.82 CCR6 (0.47) TRPA1EPHX1CCR6JAK2JAK1
SCHEMBL3477124 0.81 CTSK (0.60) TRPA1EPHX1CCR6CTSSCTSK
SCHEMBL377685 0.80 CTSS (0.48) TRPA1EPHX1CCR6JAK2JAK1
Hydrochloric Acid SCHEMBL23302911 0.79 CTSS (0.47) TRPA1EPHX1CCR6JAK2JAK1
Hydrochloric Acid SCHEMBL383062 0.79 CTSS (0.47) TRPA1EPHX1CCR6JAK2JAK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1150963-A1 SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM Aventis Pharma Deutschland GmbH (DE) 2001-11-07 EP disclosed
WO-2000046214-A1 SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2000-08-10 WO disclosed