SCHEMBL7790464

SCHEMBL7790464

CCCc1ccc(C#Cc2ccc(OCCCC(F)(F)F)cc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ACACB O00763 9/20 0.48
ALDH1A1 P00352 1/20 0.43
MAOB P27338 1/20 0.41
LMNA P02545 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
S1PR4 O95977 1/20 0.40
S1PR1 P21453 1/20 0.40
S1PR3 Q99500 1/20 0.40
S1PR5 Q9H228 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7793322 0.93 ACACB (0.47) ACACBALDH1A1MAOBLMNAS1PR4
SCHEMBL7790257 0.92 ALDH1A1 (0.50) ACACBALDH1A1LMNAS1PR4S1PR1
SCHEMBL7790483 0.90 ALDH1A1 (0.52) ACACBALDH1A1LMNAS1PR4S1PR1
SCHEMBL7794137 0.90 ALDH1A1 (0.52) ACACBALDH1A1LMNAS1PR4S1PR1
SCHEMBL7790497 0.90 ALDH1A1 (0.52) ACACBALDH1A1LMNAS1PR4S1PR1
SCHEMBL7794165 0.90 ALDH1A1 (0.52) ACACBALDH1A1LMNAS1PR4S1PR1
SCHEMBL7794619 0.90 ALDH1A1 (0.52) ACACBALDH1A1LMNAS1PR4S1PR1
SCHEMBL7794158 0.90 ALDH1A1 (0.52) ACACBALDH1A1LMNAS1PR4S1PR1
SCHEMBL7790523 0.88 CYP2D6 (0.46) ALDH1A1MAOBLMNAL3MBTL1S1PR4
SCHEMBL7794081 0.88 CYP2D6 (0.46) ALDH1A1MAOBLMNAL3MBTL1S1PR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1150937-A1 LIQUID CRYSTALLINE TRIFLUORO-SUBSTITUTED COMPOUNDS QinetiQ Limited (GB) 2001-11-07 EP disclosed
WO-2000039062-A1 LIQUID CRYSTALLINE TRIFLUORO-SUBSTITUTED COMPOUNDS THE SECRETARY OF STATE FOR DEFENCE (GB) 2000-07-06 WO disclosed