SCHEMBL7790523

SCHEMBL7790523

CCCc1ccc(-c2ccc(OCCCC(F)(F)F)cc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 5/20 0.46
CYP3A4 P08684 4/20 0.46
ALDH1A1 P00352 2/20 0.46
S1PR1 P21453 2/20 0.45
MAOB P27338 1/20 0.43
CYP19A1 P11511 4/20 0.43
CYP2C9 P11712 4/20 0.43
CYP2C19 P33261 4/20 0.43
CYP1A2 P05177 3/20 0.43
LMNA P02545 2/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
HRH3 Q9Y5N1 2/20 0.41
MEN1 O00255 1/20 0.41
USP2 O75604 1/20 0.41
MAPK1 P28482 1/20 0.41
CASP1 P29466 1/20 0.41
KMT2A Q03164 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
SLCO1B3 Q9NPD5 1/20 0.41
SLCO1B1 Q9Y6L6 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7794081 1.00 CYP2D6 (0.46) CYP2D6CYP3A4ALDH1A1S1PR1MAOB
SCHEMBL7784549 0.91 CYP3A4 (0.52) CYP2D6CYP3A4ALDH1A1S1PR1CYP19A1
SCHEMBL7793413 0.91 CYP3A4 (0.52) CYP2D6CYP3A4ALDH1A1S1PR1CYP19A1
SCHEMBL7790491 0.90 CYP3A4 (0.55) CYP2D6CYP3A4ALDH1A1S1PR1LMNA
SCHEMBL7790048 0.90 CYP3A4 (0.55) CYP2D6CYP3A4ALDH1A1S1PR1LMNA
SCHEMBL7790464 0.88 ACACB (0.48) ALDH1A1S1PR1MAOBLMNAL3MBTL1
SCHEMBL20151741 0.87 LMNA (0.50) CYP3A4ALDH1A1S1PR1MAOBLMNA
SCHEMBL7794086 0.86 RAB9A (0.52) CYP2D6CYP3A4ALDH1A1MAOBCYP19A1
SCHEMBL7794102 0.85 RAB9A (0.59) CYP2D6ALDH1A1CYP19A1CYP2C9CYP2C19
SCHEMBL17897414 0.85 CYP3A4 (0.61) CYP2D6CYP3A4ALDH1A1CYP19A1CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1150937-A1 LIQUID CRYSTALLINE TRIFLUORO-SUBSTITUTED COMPOUNDS QinetiQ Limited (GB) 2001-11-07 EP disclosed
WO-2000039062-A1 LIQUID CRYSTALLINE TRIFLUORO-SUBSTITUTED COMPOUNDS THE SECRETARY OF STATE FOR DEFENCE (GB) 2000-07-06 WO disclosed