Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 12/20 | 0.49 |
| ▸ | NPC1 | O15118 | 10/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | APP | P05067 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL515950 | 0.77 | MEN1 (0.38) | RAB9ANPC1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL827403 | 0.77 | RAB9A (0.67) | RAB9ANPC1KDM4EALDH1A1SMN1; SMN2 | |
| Hydrogen Sulfide SCHEMBL28205214 | 0.75 | RAB9A (0.64) | RAB9ANPC1KDM4EALDH1A1SMN1; SMN2 | |
| Methane SCHEMBL28056221 | 0.75 | RAB9A (0.64) | RAB9ANPC1KDM4EALDH1A1SMN1; SMN2 | |
| Hydrogen Sulfide SCHEMBL16859912 | 0.75 | RAB9A (0.64) | RAB9ANPC1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2893870 | 0.73 | RAB9A (0.46) | RAB9ANPC1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL29474819 | 0.71 | RAB9A (0.81) | RAB9ANPC1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL231307 | 0.71 | KDM4E (0.75) | RAB9ANPC1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL366824 | 0.71 | RAB9A (0.81) | RAB9ANPC1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL9228500 | 0.71 | APP (0.63) | RAB9ANPC1KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3062790-A1 | PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF CANCER | Pitney Pharmaceuticals Pty Limited (AU) | 2016-09-07 | — | — | EP | disclosed |
| WO-2015061832-A1 | PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF CANCER | PITNEY PHARMACEUTICALS PTY LIMITED (AU) | 2015-05-07 | — | — | WO | disclosed |
| EP-1150956-A1 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | MEDIVIR AB (SE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000047561-A1 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | MEDIVIR AB (SE) | 2000-08-17 | — | — | WO | disclosed |