SCHEMBL77912

SCHEMBL77912

COC(=O)C(C#N)=C(C)c1ccc(OC)cc1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.50
CA1 P00915 6/20 0.49
CA2 P00918 6/20 0.49
CES2 O00748 2/20 0.47
CES1 P23141 2/20 0.47
PLK1 P53350 1/20 0.46
MAPT P10636 2/20 0.45
PARP1 P09874 1/20 0.44
PARP10 Q53GL7 1/20 0.44
PARP2 Q9UGN5 1/20 0.44
PARP4 Q9UKK3 1/20 0.44
NPC1 O15118 2/20 0.44
RAB9A P51151 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
TP53 P04637 1/20 0.44
ALOX15 P16050 1/20 0.44
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2C19 P33261 1/20 0.43
MEN1 O00255 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5958730 1.00 HPGD (0.50) HPGDCA1CA2CES2CES1
SCHEMBL77911 1.00 HPGD (0.50) HPGDCA1CA2CES2CES1
SCHEMBL19465674 0.87 HDAC3 (0.43) HPGDCA1CA2MAPTNPC1
SCHEMBL9334030 0.86 ALDH1A1 (0.44) HPGDCES2CES1MAPTNPC1
SCHEMBL9334033 0.86 ALDH1A1 (0.44) HPGDCES2CES1MAPTNPC1
SCHEMBL23581791 0.85 HPGD (0.48) HPGDCES2CES1MAPTNPC1
SCHEMBL19007864 0.85 HPGD (0.48) HPGDCA1CA2MAPTSMN1; SMN2
SCHEMBL536535 0.85 CA1 (0.52) HPGDCA1CA2CES2CES1
SCHEMBL536534 0.85 CA1 (0.52) HPGDCA1CA2CES2CES1
SCHEMBL1553877 0.85 CYP19A1 (0.50) HPGDCA1CA2CES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4894 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1582549-B1 Flame retardant resin blends based on polymers derived from 2-hydrocarbyl-3,3-Bis(4-Hydroxyaryl)Phthalimidine monomers SABIC INNOVATIVE PLASTICS IP (NL) 2011-03-09 EP claimed
WO-2008083975-A1 LIGHT-STABILIZED COMPOSITION ISDIN S.A. (ES) 2008-07-17 WO claimed
US-6391949-B1 None US disclosed
EP-4747310-A1 NON-FLUORINATED POLYMER PROCESSING AIDS FOR DIE LIP BUILD-UP MITIGATION IN EXTRUSION OF COMPOSITIONS CONTAINING RECYCLED POLYETHYLENE Nova Chemicals (International) S.A. (CH) 2026-05-27 EP disclosed
US-20260139087-A1 COMPOUND, POLYMER, LIGHT STABILIZER COMPOSITION, RESIN COMPOSITION, COATING MATERIAL COMPOSITION, ARTICLE, SEALING MATERIAL, MOLDED ARTICLE, METHOD FOR PRODUCING WEATHER-RESISTANT RESIN COMPOSITION, AND METHOD FOR IMPROVING WEATHER RESISTANCE OF SYNTHETIC RESIN ADEKA CORPORATION (JP) 2026-05-21 US disclosed
EP-4745198-A1 RESIN COMPOSITION, MOLDED ARTICLE, RESIN ADDITIVE COMPOSITION, METHOD FOR PRODUCING RESIN COMPOSITION, METHOD FOR IMPROVING CRYSTALLINITY OF CRYSTALLINE RESIN, AND MATERIAL FOR RESIN ADDITIVE COMPOSITION ADEKA CORPORATION (JP) 2026-05-20 EP disclosed
EP-4536463-B1 PROCESS TO PREPARE THERMOPLASTIC COMPOSITIONS COMPRISING FLUORINE FREE POLYMER PROCESSING AIDS NOVA CHEMICALS INTERNATIONAL SA (CH) 2026-05-13 EP disclosed
US-12624265-B2 Antistatic agent, antistatic composition comprising same, antistatic resin composition comprising same, and molded article thereof ADEKA CORPORATION (JP) 2026-05-12 US disclosed
EP-4731708-A1 POLAR POLYMERS AS PROCESSING AIDS IN POLYETHYLENE Nova Chemicals (International) S.A. (CH) 2026-04-29 EP disclosed
EP-4728007-A1 NON-FLUORINATED POLYMER PROCESS AIDS Nova Chemicals (International) S.A. (CH) 2026-04-22 EP disclosed
EP-4729581-A1 PLASTICIZER, COMPOSITION, AND MOLDED ARTICLE ADEKA CORPORATION (JP) 2026-04-22 EP disclosed
US-3954839-A LIGHT AND HEAT STABILIZERS FOR POLYOLEFINS CIBA-GEIGY CORPORATION (US) 1976-05-04 US disclosed
US-3948854-A Salicylic acid hydrazide stabilizers for polymers CIBA-GEIGY CORPORATION (US) 1976-04-06 US disclosed
US-3944632-A Phosphoric acid anilides CIBA-GEIGY CORPORATION (US) 1976-03-16 US disclosed
US-3943098-A 1-Aza-4-thiacyclohexane-4,4-dioxide derivatives and their use as agents protecting against light rays CIBA-GEIGY CORPORATION (US) 1976-03-09 US disclosed
US-3943096-A Use of hydroxyphenylurethanes for stabilising elastomers CIBA-GEIGY CORPORATION (US) 1976-03-09 US disclosed
US-3943106-A POLYESTERS AND POLYAMIDS FROM HYDROXYBENZYLMALONIC ACID DERIVATIVES; STABILIZERS CIBA-GEIGY CORPORATION (US) 1976-03-09 US disclosed
US-3940363-A POLYMERS SANKYO COMPANY LIMITED (JA) 1976-02-24 US disclosed
US-3939175-A STABILIZER CIBA-GEIGY CORPORATION (US) 1976-02-17 US disclosed
US-3933735-A SYNTHETIC POLYMERS SANKYO COMPANY LIMITED (JA) 1976-01-20 US disclosed