Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 9/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RXRA | P19793 | 2/20 | 0.42 |
| ▸ | RXRB | P28702 | 2/20 | 0.42 |
| ▸ | RXRG | P48443 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7799879 | 0.86 | RXRA (0.44) | MRGPRX4LRRK2NPC1RXRARXRB | |
| SCHEMBL7953912 | 0.81 | MRGPRX4 (0.56) | MRGPRX4LRRK2NPC1RXRARXRB | |
| SCHEMBL7791856 | 0.81 | MRGPRX4 (0.48) | MRGPRX4LRRK2NPC1RXRARXRB | |
| SCHEMBL8428710 | 0.79 | MAPT (0.40) | LRRK2NPC1RAB9AMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8335173 | 0.78 | MAPT (0.40) | LRRK2NPC1RAB9AMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7801900 | 0.77 | KDM4E (0.38) | RAB9AMEN1KMT2ASMN1; SMN2CLCN2 | |
| SCHEMBL11242220 | 0.74 | S1PR1 (0.61) | MRGPRX4LRRK2NPC1RAB9AMEN1 | |
| SCHEMBL16586292 | 0.74 | RXRA (0.57) | MRGPRX4RXRARXRBRXRGL3MBTL1 | |
| SCHEMBL7797854 | 0.74 | TMPRSS4 (0.41) | RAB9AMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL8070202 | 0.73 | SCN9A (0.39) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0794172-B1 | Orthosubstituted benzoylguanidines | HOECHST AG (DE) | 2001-10-24 | — | — | EP | disclosed |
| CN-1071318-C | Ortho-substd. benzoyl guanidines, their preparing process and use as medicine and diagnostic reagent, and medicine contg. same | HOECHST AG (DE) | 2001-09-19 | — | — | CN | disclosed |
| US-6262123-B1 | AS ANTIARRHYTHMIC AGENTS HAVING CARDIOPROTECTIVE COMPONENT, FOR PROPHYLAXIS AND TREATMENT OF INFARCTION AND ANGINA PECTORIS; FOR INHIBITION OF PATHOPHYSIOLOGICAL PROCESSES ASSOCIATED WITH GENESIS OF ISCHEMICALLY INDUCED DAMAGE | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-07-17 | — | — | US | disclosed |
| CN-1160042-A | Ortho-substd. benzoyl guanidines, their preparing process and use as medicine and diagnostic reagent, and medicine contg. same | HOECHST AG (DE) | 1997-09-24 | — | — | CN | disclosed |
| EP-0794172-A1 | Orthosubstituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent and a medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-09-10 | — | — | EP | disclosed |