Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS4 | Q9NRS4 | 11/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | P2RX1 | P51575 | 3/20 | 0.35 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MYLK | Q15746 | 1/20 | 0.35 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.35 |
| ▸ | PYGL | P06737 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7791912 | 0.99 | TMPRSS4 (0.40) | TMPRSS4RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL8428726 | 0.84 | TP53 (0.39) | TMPRSS4RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL7799902 | 0.84 | ALDH1A1 (0.38) | TMPRSS4RAB9ATP53P2RX1CYP1A2 | |
| Hydrochloric Acid SCHEMBL8337102 | 0.83 | TP53 (0.38) | TMPRSS4RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL8426433 | 0.83 | POLB (0.38) | TMPRSS4RAB9ATP53MAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7791930 | 0.83 | ALDH1A1 (0.38) | TMPRSS4RAB9ATP53P2RX1CYP1A2 | |
| Hydrochloric Acid SCHEMBL8332842 | 0.82 | POLB (0.38) | TMPRSS4RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL8428710 | 0.81 | MAPT (0.40) | RAB9AMAPTMEN1KMT2APYGL | |
| SCHEMBL8428388 | 0.81 | S1PR1 (0.39) | TMPRSS4RAB9ATP53MAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8333467 | 0.80 | S1PR1 (0.38) | TMPRSS4RAB9ATP53MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0794172-B1 | Orthosubstituted benzoylguanidines | HOECHST AG (DE) | 2001-10-24 | — | — | EP | claimed |
| EP-0811610-B1 | Ortho-substituted benzoylguanidines process for their preparation, their use as medicament or diagnostic agent and medicaments containing them | HOECHST AG (DE) | 2001-11-28 | — | — | EP | disclosed |
| CN-1064956-C | Ortho-substd. benzoyl guanidine, its preparing method, use thereof and medicine contg. same | HOECHST AG (DE) | 2001-04-25 | — | — | CN | disclosed |
| CN-1175572-A | Ortho-substd. benzoyl guanidine, its preparing method, use thereof and medicine contg. same | HOECHST AG (DE) | 1998-03-11 | — | — | CN | disclosed |
| EP-0811610-A1 | Ortho-substituted benzoylguanidines process for their preparation, their use as medicament or diagnostic agent and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-12-10 | — | — | EP | disclosed |