Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 4/20 | 0.46 |
| ▸ | XIAP | P98170 | 2/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 6/20 | 0.37 |
| ▸ | F3 | P13726 | 6/20 | 0.37 |
| ▸ | F2 | P00734 | 3/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7794624 | 0.94 | GHSR (0.45) | GHSRXIAPAGTR1F7F3 | |
| SCHEMBL7791796 | 0.94 | GHSR (0.47) | GHSRXIAPAGTR1F7F3 | |
| SCHEMBL7786077 | 0.92 | GHSR (0.53) | GHSRXIAPAGTR1MTNR1AHTR7 | |
| SCHEMBL7785739 | 0.92 | GHSR (0.54) | GHSRXIAPAGTR1MTNR1AHTR7 | |
| SCHEMBL7794398 | 0.91 | GHSR (0.55) | GHSRXIAPAGTR1F7F3 | |
| SCHEMBL7791742 | 0.91 | GHSR (0.54) | GHSRXIAPAGTR1MTNR1AHTR7 | |
| SCHEMBL7785953 | 0.90 | GHSR (0.47) | GHSRXIAPAGTR1F7F3 | |
| SCHEMBL7791823 | 0.88 | GHSR (0.46) | GHSRXIAPAGTR1F7F3 | |
| SCHEMBL8331161 | 0.88 | GHSR (0.56) | GHSRXIAPAGTR1F7F3 | |
| SCHEMBL7796068 | 0.87 | GHSR (0.43) | GHSRXIAPAGTR1F7F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0659179-B1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | claimed |
| EP-0659179-B1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |