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SCHEMBL7785953

SCHEMBL7785953

CCC(=O)N[C@@H]1CSc2cc(F)ccc2N(Cc2ccc(-c3ccccc3CNC(N)=O)cc2)C1=O

nearest known ligand 0.47

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ GHSR Q92847 4/20 0.47
▸ XIAP P98170 2/20 0.40
▸ F7 P08709 12/20 0.39
▸ F3 P13726 12/20 0.39
▸ F2 P00734 5/20 0.39
▸ AGTR1 P30556 1/20 0.38
▸ F10 P00742 3/20 0.36
▸ SSTR5 P35346 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7791888 0.94 GHSR (0.46) GHSRXIAPF7F3F2
SCHEMBL8331047 0.94 GHSR (0.48) GHSRXIAPF7F3F2
SCHEMBL7794362 0.92 GHSR (0.54) GHSRXIAPF7F3F2
SCHEMBL7786886 0.92 GHSR (0.55) GHSRXIAPF7F3F2
SCHEMBL7786058 0.91 GHSR (0.57) GHSRXIAPF7F3F2
SCHEMBL7792151 0.91 GHSR (0.55) GHSRXIAPF7F3F2
SCHEMBL7792009 0.90 GHSR (0.46) GHSRXIAPF7F3F2
SCHEMBL7791823 0.90 GHSR (0.46) GHSRXIAPF7F3F2
SCHEMBL7791678 0.87 GHSR (0.57) GHSRXIAPF7F3F2
SCHEMBL7794434 0.87 GHSR (0.44) GHSRXIAPF7F3F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0659179-B1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO INC (US) 2001-11-21 — — EP claimed
EP-0659179-B1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO INC (US) 2001-11-21 — — EP disclosed