Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.45 |
| ▸ | ELANE | P08246 | 2/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8381770 | 0.95 | MAPT (0.46) | MAPTCHRNA7KMT2APTPN1ELANE | |
| SCHEMBL7796371 | 0.94 | MAPT (0.49) | MAPTCHRNA7KMT2APTPN1ESR1 | |
| SCHEMBL7786494 | 0.93 | MAPT (0.56) | MAPTCHRNA7KMT2AELANEHTR1D | |
| SCHEMBL7786378 | 0.92 | KMT2A (0.49) | MAPTCHRNA7KMT2APTPN1ESR1 | |
| SCHEMBL7796335 | 0.92 | KMT2A (0.51) | MAPTCHRNA7KMT2APTPN1ELANE | |
| SCHEMBL7791978 | 0.91 | MAPT (0.51) | MAPTCHRNA7KMT2AELANEHTR1D | |
| SCHEMBL7792157 | 0.91 | MAPT (0.54) | MAPTCHRNA7KMT2AELANEHTR1D | |
| SCHEMBL8382358 | 0.89 | MAPT (0.47) | MAPTCHRNA7KMT2APTPN1ELANE | |
| SCHEMBL7786093 | 0.89 | MAPT (0.50) | MAPTCHRNA7KMT2APTPN1ELANE | |
| SCHEMBL7792642 | 0.89 | ALDH1A1 (0.48) | MAPTCHRNA7KMT2APTPN1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906268-B1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | AVENTIS PHARMA INC (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6004959-A | HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |