Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7795792 | 0.97 | USP2 (0.51) | ALDH1A1KDM4EHTTSIGMAR1ADORA3 | |
| SCHEMBL7786488 | 0.94 | ADORA2A (0.56) | ALDH1A1KDM4ETSHRADORA3ADORA2A | |
| SCHEMBL7794714 | 0.90 | HRH3 (0.53) | ALDH1A1KDM4ETSHRADORA3ADORA2A | |
| SCHEMBL7786474 | 0.89 | HRH3 (0.55) | ALDH1A1TSHRADORA3ADORA2AADORA2B | |
| SCHEMBL7791807 | 0.89 | ALDH1A1 (0.57) | ALDH1A1KDM4EHTTTSHRSMN1; SMN2 | |
| SCHEMBL7794749 | 0.87 | HRH3 (0.57) | ADORA3ADORA2AADORA2BADORA1KCNA3 | |
| SCHEMBL7786125 | 0.87 | MAPK1 (0.51) | ALDH1A1KDM4EHTTSIGMAR1ADORA3 | |
| SCHEMBL7792591 | 0.86 | HRH3 (0.59) | KDM4EADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL7792581 | 0.85 | USP2 (0.54) | ALDH1A1KDM4EHTTTSHRSMN1; SMN2 | |
| SCHEMBL7796341 | 0.85 | MAPK14 (0.50) | ALDH1A1KDM4EHTTSIGMAR1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906268-B1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | AVENTIS PHARMA INC (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6004959-A | HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0906268-A1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997045397-A1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1997-12-04 | — | — | WO | disclosed |