Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Salicyladehyde. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.50 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | STS | P08842 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicyladehyde SCHEMBL7798137 | 0.90 | TRIM24 (0.62) | TRIM24TRIM33L3MBTL1NFKB1CA1 | |
| Salicyladehyde SCHEMBL15016 | 0.85 | TRIM24 (0.69) | TRIM24TRIM33NFKB1CA1CA2 | |
| Cyclohexylamine SCHEMBL7802530 | 0.85 | MAPT (0.37) | L3MBTL1PTGDR2SRCNPC1ALDH1A1 | |
| Cyclohexylamine SCHEMBL7801529 | 0.85 | NPC1 (0.44) | L3MBTL1PTGDR2ERN1SRCNPC1 | |
| Cyclohexylamine SCHEMBL7802630 | 0.83 | PPARG (0.44) | ALDH1A1HPGDKDM4EKMT2AMEN1 | |
| Benzaldehyde SCHEMBL7798223 | 0.82 | ALDH1A1 (0.44) | L3MBTL1PTGDR2NPC1ALDH1A1RAB9A | |
| 2-Methoxybenzaldehyde SCHEMBL7801604 | 0.82 | ALDH1A1 (0.46) | PTGDR2ERN1SRCNPC1ALDH1A1 | |
| Cyclohexylamine SCHEMBL7798069 | 0.82 | F2R (0.38) | L3MBTL1PTGDR2SRCALDH1A1KMT2A | |
| Cyclohexylamine SCHEMBL7802045 | 0.80 | ERN1 (0.39) | ERN1NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| Salicyladehyde SCHEMBL27831448 | 0.79 | TRIM24 (0.64) | TRIM24TRIM33L3MBTL1NFKB1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076649-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 2001-02-21 | — | — | EP | disclosed |
| WO-1999055679-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 1999-11-04 | — | — | WO | disclosed |