Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MITF | O75030 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CES2 | O00748 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16234831 | 0.83 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL76893 | 0.82 | SMN1; SMN2 (0.54) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL76588 | 0.82 | SMN1; SMN2 (0.54) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL16235129 | 0.81 | CCR1 (0.58) | NPC1RAB9ASMN1; SMN2POLBCES2 | |
| SCHEMBL16234833 | 0.80 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL28043395 | 0.75 | CES1 (0.66) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL10763104 | 0.75 | NPC1 (0.65) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL10768107 | 0.75 | NPC1 (0.65) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL10763115 | 0.75 | NPC1 (0.65) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL7897280 | 0.75 | CA2 (0.65) | RAB9ASMN1; SMN2POLBCA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129355-B2 | Nuclear receptor-based inducible gene expression system; modulating the expression of a gene in a host cell by introducing into the host cell a gene expression modulation system and activating that system using 5-ethyl-2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid (1-benzoyl-cyclopentyl)-amide | INTREXON CORPORATION (US) | 2012-03-06 | — | — | US | disclosed |