Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | CTSG | P08311 | 1/20 | 0.46 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
| ▸ | CCR6 | P51684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL76893 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAALDH1A1NPC1RAB9A | |
| SCHEMBL16235129 | 0.87 | CCR1 (0.58) | SMN1; SMN2ALDH1A1NPC1RAB9APOLB | |
| SCHEMBL15260867 | 0.84 | CA2 (0.66) | SMN1; SMN2LMNAALDH1A1NPC1RAB9A | |
| SCHEMBL77928 | 0.82 | NPC1 (0.56) | SMN1; SMN2ALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL7897280 | 0.80 | CA2 (0.65) | SMN1; SMN2LMNAALDH1A1RAB9APOLB | |
| SCHEMBL4680240 | 0.80 | CA2 (0.65) | SMN1; SMN2LMNAALDH1A1RAB9APOLB | |
| SCHEMBL4685570 | 0.80 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNAALDH1A1NPC1RAB9A | |
| SCHEMBL7017250 | 0.79 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNAALDH1A1NPC1MEN1 | |
| SCHEMBL4681864 | 0.78 | CA2 (0.54) | SMN1; SMN2LMNAALDH1A1RAB9ACA2 | |
| SCHEMBL76387 | 0.77 | KCNK3 (0.47) | SMN1; SMN2LMNAALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129355-B2 | Nuclear receptor-based inducible gene expression system; modulating the expression of a gene in a host cell by introducing into the host cell a gene expression modulation system and activating that system using 5-ethyl-2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid (1-benzoyl-cyclopentyl)-amide | INTREXON CORPORATION (US) | 2012-03-06 | — | — | US | disclosed |
| US-8129355-B2 | Nuclear receptor-based inducible gene expression system; modulating the expression of a gene in a host cell by introducing into the host cell a gene expression modulation system and activating that system using 5-ethyl-2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid (1-benzoyl-cyclopentyl)-amide | INTREXON CORPORATION (US) | 2012-03-06 | — | — | US | disclosed |