SCHEMBL7793196

SCHEMBL7793196

Cc1c(Cl)cccc1OCc1ccccc1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.76
TDP1 Q9NUW8 2/20 0.76
L3MBTL1 Q9Y468 2/20 0.76
MAPK1 P28482 1/20 0.76
MRGPRX4 Q96LA9 2/20 0.67
HTR1A P08908 4/20 0.54
ADRA1D P25100 3/20 0.54
ADRA1A P35348 3/20 0.54
ADRA1B P35368 3/20 0.54
HPGD P15428 2/20 0.51
RXRA P19793 1/20 0.51
RXRB P28702 1/20 0.51
MAPK14 Q16539 2/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
MEN1 O00255 1/20 0.51
NPC1 O15118 1/20 0.51
MITF O75030 1/20 0.51
TP53 P04637 1/20 0.51
XBP1 P17861 1/20 0.51
NFKB1 P19838 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19612191 0.87 MAPT (1.00) MAPTTDP1L3MBTL1MAPK1MRGPRX4
SCHEMBL3047774 0.83 HPGD (0.69) MAPTTDP1L3MBTL1MAPK1HTR1A
SCHEMBL2880443 0.81 MAPT (0.81) MAPTTDP1L3MBTL1MAPK1HTR1A
SCHEMBL22480789 0.81 MRGPRX4 (1.00) MAPTMRGPRX4HPGDSMN1; SMN2MEN1
SCHEMBL9007487 0.81 MAPT (0.80) MAPTTDP1L3MBTL1MAPK1HTR1A
SCHEMBL10650287 0.80 MRGPRX4 (0.53) MAPTTDP1L3MBTL1MAPK1MRGPRX4
SCHEMBL19612456 0.80 HTR1A (0.63) MAPTTDP1L3MBTL1MAPK1MRGPRX4
SCHEMBL1253794 0.80 MAPT (0.85) MAPTTDP1L3MBTL1MAPK1MRGPRX4
SCHEMBL7450789 0.79 MAPT (0.71) MAPTTDP1L3MBTL1MAPK1MRGPRX4
SCHEMBL19612205 0.79 MAPT (0.64) MAPTTDP1L3MBTL1MAPK1MRGPRX4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0857713-B1 Process for the preparation of 3-hydroxy- and 3-acetoxy-2-methylbenzoic acid CLARIANT GMBH (DE) 2001-06-13 EP claimed
US-5910605-A Process for the preparation of 3-hydroxy-2-methylbenzoic acid and 3-acetoxy-2-methylbenzoic CLARIANT GMBH (DE) 1999-06-08 US claimed
EP-0857713-A1 Process for the preparation of 3-hydroxy- and 3-acetoxy-2-methylbenzoic acid Clariant GmbH (DE) 1998-08-12 EP claimed
JP-10273475-A None JP disclosed
EP-0857713-B1 Process for the preparation of 3-hydroxy- and 3-acetoxy-2-methylbenzoic acid CLARIANT GMBH (DE) 2001-06-13 EP disclosed
US-5910605-A Process for the preparation of 3-hydroxy-2-methylbenzoic acid and 3-acetoxy-2-methylbenzoic CLARIANT GMBH (DE) 1999-06-08 US disclosed
US-5910605-A Process for the preparation of 3-hydroxy-2-methylbenzoic acid and 3-acetoxy-2-methylbenzoic CLARIANT GMBH (DE) 1999-06-08 US disclosed
JP-H10273475-A PRODUCTION OF 3-HYDROXY-2-METHYLBENZOIC ACID AND 3-ACETOXY-2-METHYLBENZOIC ACID CLARIANT GMBH 1998-10-13 JP disclosed
EP-0857713-A1 Process for the preparation of 3-hydroxy- and 3-acetoxy-2-methylbenzoic acid Clariant GmbH (DE) 1998-08-12 EP disclosed
EP-0857713-A1 Process for the preparation of 3-hydroxy- and 3-acetoxy-2-methylbenzoic acid Clariant GmbH (DE) 1998-08-12 EP disclosed