SCHEMBL7793633

SCHEMBL7793633

O=C(O)c1ccc(C23CC4CC(CC(C4)C2)C3)c(OCc2ccccc2)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FAAH O00519 3/20 0.50
CNR2 P34972 3/20 0.50
CNR1 P21554 1/20 0.50
RARB P10826 4/20 0.47
RARG P13631 4/20 0.47
MEN1 O00255 4/20 0.47
KMT2A Q03164 4/20 0.47
RARA P10276 3/20 0.47
NR1I2 O75469 1/20 0.47
LMNA P02545 1/20 0.47
PGR P06401 1/20 0.47
HSPD1 P10809 1/20 0.47
GOT1 P17174 1/20 0.47
GLRA1 P23415 1/20 0.47
BLM P54132 1/20 0.47
HSPE1 P61604 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
PTGER1 P34995 2/20 0.46
RXRA P19793 1/20 0.46
RXRB P28702 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7795284 0.90 RARA (0.53) FAAHCNR2CNR1RARBRARG
Hydrochloric Acid SCHEMBL9123492 0.89 RARA (0.53) FAAHCNR2CNR1RARBRARG
SCHEMBL9126612 0.89 FAAH (0.49) FAAHCNR2CNR1MEN1KMT2A
SCHEMBL6032912 0.84 FAAH (0.41) FAAHCNR2CNR1RARBRARG
SCHEMBL9123487 0.82 FAAH (0.49) FAAHCNR2CNR1RARBRARG
SCHEMBL7518648 0.82 MEN1 (0.64) FAAHCNR2CNR1RARBRARG
SCHEMBL8615102 0.81 RARA (0.48) FAAHCNR2CNR1RARBRARG
SCHEMBL3311321 0.81 SLC6A4 (0.50) FAAHCNR2CNR1MEN1KMT2A
SCHEMBL28094057 0.81 FAAH (0.48) FAAHCNR2CNR1RARBRARG
SCHEMBL7796952 0.81 FAAH (0.54) FAAHCNR2CNR1RARBRARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0643701-B1 BENZIMIDAZOLE-DERIVED COMPOUNDS, METHOD FOR PREPARING SAME, AND THERAPEUTICAL AND COSMETIC USES THEREOF CT INTERNAT DE RECH S BR DERMA (FR) 2001-12-05 EP disclosed
US-5446059-A Treating or preventing inflammatory or immunoallergic conditions CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) 1995-08-29 US disclosed
EP-0643701-A1 BENZIMIDAZOLE-DERIVED COMPOUNDS, METHOD FOR PREPARING SAME, AND THERAPEUTICAL AND COSMETIC USES THEREOF CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA) (FR) 1995-03-22 EP disclosed
WO-1992021663-A1 BENZIMIDAZOLE-DERIVED COMPOUNDS, METHOD FOR PREPARING SAME, AND THERAPEUTICAL AND COSMETIC USES THEREOF CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) 1992-12-10 WO disclosed