Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | PPARA | Q07869 | 3/20 | 0.54 |
| ▸ | PPARG | P37231 | 2/20 | 0.54 |
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7801086 | 0.96 | TSHR (0.71) | TSHRPPARAPPARGPLA2G4BCYP3A4 | |
| SCHEMBL7802428 | 0.95 | TSHR (0.74) | TSHRPPARAPPARGPLA2G4BCYP3A4 | |
| SCHEMBL7801094 | 0.92 | TSHR (0.59) | TSHRPPARAPPARGPLA2G4BCYP3A4 | |
| SCHEMBL29577774 | 0.85 | TP53 (0.62) | TSHRPPARAPPARGCYP3A4TP53 | |
| SCHEMBL655678 | 0.85 | TP53 (0.62) | TSHRPPARAPPARGCYP3A4TP53 | |
| SCHEMBL109886 | 0.85 | TSHR (0.86) | TSHRCYP3A4TP53ALDH1A1CYP1A2 | |
| SCHEMBL27483976 | 0.84 | CYP1A2 (0.59) | TSHRPLA2G4BCYP3A4ALDH1A1TDP1 | |
| SCHEMBL202778 | 0.84 | PLA2G4B (0.58) | PPARAPPARGPLA2G4BALDH1A1TDP1 | |
| SCHEMBL31609710 | 0.84 | PLA2G4B (0.58) | PPARAPPARGPLA2G4BALDH1A1TDP1 | |
| SCHEMBL11655422 | 0.82 | LTA4H (0.61) | TSHRPLA2G4BFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900255-B1 | DONOR-SUBSTITUTED OXINDIGO DERIVATIVES AND THEIR USE AS COLOURANTS | CIBA SC HOLDING AG (CH) | 2001-12-19 | — | — | EP | disclosed |
| US-6156914-A | Donor-substituted oxindigo derivatives and their use as colorants | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2000-12-05 | — | — | US | disclosed |
| EP-0900255-A1 | DONOR-SUBSTITUTED OXINDIGO DERIVATIVES AND THEIR USE AS COLOURANTS | Ciba SC Holding AG (CH) | 1999-03-10 | — | — | EP | disclosed |
| WO-1997041176-A1 | DONOR-SUBSTITUTED OXINDIGO DERIVATIVES AND THEIR USE AS COLOURANTS | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 1997-11-06 | — | — | WO | disclosed |