Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | KMT5B | Q4FZB7 | 2/20 | 0.54 |
| ▸ | KMT5C | Q86Y97 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | ALPI | P09923 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31196551 | 0.98 | NPC1 (0.60) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL1159931 | 0.92 | RAB9A (0.50) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL3786467 | 0.85 | KMT5B (0.54) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL27644583 | 0.84 | RAB9A (0.44) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL7794045 | 0.84 | RAB9A (0.48) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL2092958 | 0.84 | RAB9A (0.44) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL16334269 | 0.81 | KMT5B (0.51) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL3783518 | 0.81 | IDO1 (0.46) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL3712720 | 0.81 | RAB9A (0.46) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL3784337 | 0.81 | MAPT (0.51) | RAB9ANPC1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150963-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Aventis Pharma Deutschland GmbH (DE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046214-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-08-10 | — | — | WO | disclosed |