Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KMT5B | Q4FZB7 | 1/20 | 0.40 |
| ▸ | KMT5C | Q86Y97 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1159931 | 0.91 | RAB9A (0.50) | RAB9ANPC1MAPK1MEN1KMT2A | |
| SCHEMBL7794566 | 0.84 | RAB9A (0.59) | RAB9ANPC1MAPK1MEN1KMT2A | |
| SCHEMBL12908037 | 0.83 | HSP90AA1 (0.43) | RAB9ANPC1MAPTGRM2HSP90AA1 | |
| SCHEMBL7185539 | 0.83 | HSP90AA1 (0.43) | MAPK1MAPTADORA1HSP90AA1ALDH1A1 | |
| SCHEMBL7185544 | 0.83 | HSP90AA1 (0.43) | MAPK1MAPTADORA1HSP90AA1ALDH1A1 | |
| SCHEMBL19139554 | 0.83 | HSP90AA1 (0.43) | RAB9ANPC1MAPTGRM2HSP90AA1 | |
| SCHEMBL12908038 | 0.83 | HSP90AA1 (0.43) | RAB9ANPC1MAPTGRM2HSP90AA1 | |
| SCHEMBL8056339 | 0.83 | GRM2 (0.42) | GRM2ADORA1HSP90AA1HTT | |
| SCHEMBL738696 | 0.83 | HTT (0.56) | MAPK1MEN1KMT2AMAPTGRM2 | |
| SCHEMBL31196551 | 0.82 | NPC1 (0.60) | RAB9ANPC1MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150963-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Aventis Pharma Deutschland GmbH (DE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046214-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-08-10 | — | — | WO | disclosed |