Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 5/20 | 0.54 |
| ▸ | THRB | P10828 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6658489 | 0.82 | THRA (0.60) | THRATHRBEPHX1EPHX2 | |
| SCHEMBL6658672 | 0.81 | THRA (0.57) | THRATHRB | |
| SCHEMBL6666173 | 0.81 | THRA (0.53) | THRATHRB | |
| SCHEMBL6661412 | 0.81 | THRA (0.53) | THRATHRB | |
| SCHEMBL7795929 | 0.81 | THRA (0.53) | THRATHRB | |
| SCHEMBL6664791 | 0.80 | THRA (0.54) | THRATHRBALDH1A1 | |
| SCHEMBL6658230 | 0.80 | THRA (0.62) | THRATHRBEPHX1EPHX2 | |
| SCHEMBL6657705 | 0.79 | THRB (0.52) | THRATHRBALDH1A1 | |
| SCHEMBL6657368 | 0.79 | THRA (0.56) | THRATHRBALDH1A1EPHX1EPHX2 | |
| SCHEMBL6658717 | 0.78 | THRA (0.54) | THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1157001-A1 | OXAMIC ACIDS AND DERIVATIVES AS THYROID RECEPTOR LIGANDS | Pfizer Products Inc. (US) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000051971-A1 | OXAMIC ACIDS AND DERIVATIVES AS THYROID RECEPTOR LIGANDS | PFIZER PRODUCTS INC. (US) | 2000-09-08 | — | — | WO | disclosed |