SCHEMBL7795392

SCHEMBL7795392

CC(C)(C)OC(=O)NCc1ccccc1-c1ccc(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNA5 P22460 2/20 0.45
HDAC1 Q13547 2/20 0.41
PTPN1 P18031 1/20 0.41
CTSS P25774 1/20 0.39
CTSK P43235 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
AKT1 P31749 1/20 0.39
EPHX1 P07099 1/20 0.39
AGTR1 P30556 1/20 0.39
AGTR2 P50052 1/20 0.39
PPARA Q07869 2/20 0.39
SYK P43405 1/20 0.39
GRM2 Q14416 1/20 0.38
PDCD1 Q15116 1/20 0.38
CD274 Q9NZQ7 1/20 0.38
NTSR1 P30989 1/20 0.38
HDAC10 Q969S8 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
NAMPT P43490 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9090245 0.86 KCNA5 (0.47) KCNA5HDAC1PTPN1MEN1KMT2A
SCHEMBL7791651 0.81 KCNA5 (0.54) KCNA5HDAC1CTSSCTSKAKT1
SCHEMBL14558984 0.80 GLS (0.48) HDAC1CTSSCTSKMEN1KMT2A
SCHEMBL8698193 0.79 KCNA5 (0.52) KCNA5HDAC1PTPN1CTSSCTSK
SCHEMBL8697069 0.79 KCNA5 (0.47) KCNA5HDAC1PTPN1AKT1AGTR1
SCHEMBL7862318 0.78 KCNA5 (0.53) KCNA5HDAC1AGTR1AGTR2HDAC10
SCHEMBL3750932 0.77 KCNA5 (0.54) KCNA5HDAC1CTSSCTSKGRM2
SCHEMBL12050574 0.77 KCNA5 (0.54) KCNA5HDAC1AKT1AGTR1AGTR2
SCHEMBL2936587 0.76 PPARA (0.46) HDAC1CTSSCTSKMEN1KMT2A
SCHEMBL7384539 0.74 ACE (0.58) PTPN1CTSSCTSKPPARAPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0659179-B1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO INC (US) 2001-11-21 EP disclosed
US-6211174-B1 OSTEOPOROSIS; MILK PRODUCTION AND CARCASS QUALITY IN LIVESTOCK; SHORT STATURE; METABOLIC DISORDERS MERCK & CO., INC. 2001-04-03 US disclosed
US-5968924-A HAVE THE ABILITY TO STIMULATE THE RELEASE OF NATURAL OR ENDOGENOUS GROWTH HORMONE; TREATMENT OF OBESITY, OSTEOPOROSIS MERCK & CO., INC. (US) 1999-10-19 US disclosed
US-5672596-A ANIMAL GROWTH CONTROLLERS MERCK & CO., INC. (US) 1997-09-30 US disclosed
US-5545735-A ANIMAL GROWTH REGULATORS MERCK & CO., INC. (US) 1996-08-13 US disclosed
US-5438136-A Benzo-fused macrocycles promote release of growth hormone MERCK & CO., INC. (US) 1995-08-01 US disclosed
WO-1995012598-A1 BENZO-FUSED MACROCYCLES PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO., INC. (US) 1995-05-11 WO disclosed
WO-1995009633-A1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO., INC. (US) 1995-04-13 WO disclosed
WO-1994005634-A1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO., INC. (US) 1994-03-17 WO disclosed