Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
| ▸ | SELE | P16581 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 2/20 | 0.34 |
| ▸ | OXTR | P30559 | 2/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7795519 | 0.79 | ICAM1 (0.39) | ICAM1SELEKDM4CITGB1ITGA4 | |
| SCHEMBL7795558 | 0.76 | ALDH1A1 (0.43) | ICAM1SELEKDM4CITGB1ITGA4 | |
| SCHEMBL11059345 | 0.75 | GBA1 (0.40) | ITGB1ITGA4OXTRAVPR1ANAAA | |
| SCHEMBL4184332 | 0.75 | KDM4C (0.47) | ICAM1SELEKDM4CCREBBPEP300 | |
| SCHEMBL20658893 | 0.74 | ICAM1 (0.39) | ICAM1SELEKDM4CCREBBPEP300 | |
| SCHEMBL14650437 | 0.74 | KDM4C (0.39) | ICAM1SELEKDM4CITGB1ITGA4 | |
| SCHEMBL11258174 | 0.73 | KDM4C (0.46) | ICAM1SELEKDM4CCREBBPEP300 | |
| SCHEMBL7796030 | 0.73 | ITGB1 (0.43) | ITGB1ITGA4CREBBPEP300MEN1 | |
| SCHEMBL1732484 | 0.72 | ALDH1A1 (0.46) | ICAM1SELEMEN1KMT2A | |
| SCHEMBL16482755 | 0.72 | ICAM1 (0.40) | ICAM1SELEKDM4CCREBBPEP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0659179-B1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| US-5968924-A | HAVE THE ABILITY TO STIMULATE THE RELEASE OF NATURAL OR ENDOGENOUS GROWTH HORMONE; TREATMENT OF OBESITY, OSTEOPOROSIS | MERCK & CO., INC. (US) | 1999-10-19 | — | — | US | disclosed |
| US-5672596-A | ANIMAL GROWTH CONTROLLERS | MERCK & CO., INC. (US) | 1997-09-30 | — | — | US | disclosed |
| EP-0659179-A4 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. | MERCK & CO INC (US) | 1995-08-09 | — | — | EP | disclosed |
| EP-0659179-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1995-06-28 | — | — | EP | disclosed |
| WO-1994005634-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-03-17 | — | — | WO | disclosed |
| US-5283241-A | Animal growth regulators | MERCK & CO., INC. (US) | 1994-02-01 | — | — | US | disclosed |