Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 1/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 13/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.42 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8714080 | 0.76 | MAPT (0.55) | ALDH1A1HTTCREBBPMEN1KMT2A | |
| SCHEMBL7795519 | 0.76 | ICAM1 (0.39) | ITGB1ITGA4ALDH1A1CREBBPEP300 | |
| SCHEMBL3809200 | 0.75 | KMT2A (0.48) | ALDH1A1NPSR1CREBBPEP300MEN1 | |
| SCHEMBL11059345 | 0.75 | GBA1 (0.40) | ITGB1ITGA4 | |
| SCHEMBL7785749 | 0.74 | CHRM3 (0.48) | CHRM3ALDH1A1HTTNPSR1MEN1 | |
| SCHEMBL7795558 | 0.74 | ALDH1A1 (0.43) | ITGB1ITGA4ALDH1A1CREBBPEP300 | |
| SCHEMBL16639666 | 0.74 | CREBBP (0.48) | ALDH1A1HTTNPSR1CREBBPEP300 | |
| SCHEMBL7795616 | 0.73 | ICAM1 (0.36) | ITGB1ITGA4CREBBPEP300MEN1 | |
| SCHEMBL1732484 | 0.73 | ALDH1A1 (0.46) | ALDH1A1NPSR1MEN1KMT2ATDP1 | |
| SCHEMBL4184332 | 0.72 | KDM4C (0.47) | CREBBPEP300MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0659179-B1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| US-5968924-A | HAVE THE ABILITY TO STIMULATE THE RELEASE OF NATURAL OR ENDOGENOUS GROWTH HORMONE; TREATMENT OF OBESITY, OSTEOPOROSIS | MERCK & CO., INC. (US) | 1999-10-19 | — | — | US | disclosed |
| US-5672596-A | ANIMAL GROWTH CONTROLLERS | MERCK & CO., INC. (US) | 1997-09-30 | — | — | US | disclosed |
| EP-0711287-A4 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 1996-08-28 | — | — | EP | disclosed |
| EP-0711287-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1996-05-15 | — | — | EP | disclosed |
| EP-0659179-A4 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. | MERCK & CO INC (US) | 1995-08-09 | — | — | EP | disclosed |
| US-5430144-A | E.g, N-(1-((2'-((methoxycarbonyl)amino)(1,1'-biphenyl)-4-yl) methyl)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl)-3 ((fur-2-yl)methyl)amino-3-methylbutanamide | MERCK & CO., INC. (US) | 1995-07-04 | — | — | US | disclosed |
| EP-0659179-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1995-06-28 | — | — | EP | disclosed |
| WO-1995003290-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1995-02-02 | — | — | WO | disclosed |
| WO-1994005634-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-03-17 | — | — | WO | disclosed |
| US-5283241-A | Animal growth regulators | MERCK & CO., INC. (US) | 1994-02-01 | — | — | US | disclosed |