Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7786415 | 0.97 | KEAP1 (0.48) | KEAP1KMT2AHPGDLMNATSHR | |
| SCHEMBL7792245 | 0.91 | KEAP1 (0.43) | KEAP1KMT2AHPGDLMNATSHR | |
| SCHEMBL7786572 | 0.88 | ALDH1A1 (0.41) | KEAP1KMT2AHPGDLMNATSHR | |
| SCHEMBL7795954 | 0.85 | KEAP1 (0.59) | KEAP1KMT2AHPGDLMNATSHR | |
| SCHEMBL7786417 | 0.84 | POLB (0.48) | KMT2AHPGDNPC1ALDH1A1RAB9A | |
| SCHEMBL7792184 | 0.81 | KMT2A (0.45) | KEAP1KMT2AHPGDLMNATSHR | |
| SCHEMBL7796136 | 0.80 | ALDH1A1 (0.49) | KMT2AHPGDALDH1A1HSD17B10KDM4E | |
| SCHEMBL14134397 | 0.74 | IRAK4 (0.58) | KEAP1LMNATSHRALDH1A1TP53 | |
| SCHEMBL7291892 | 0.74 | NPC1 (0.55) | KMT2AHPGDLMNATSHRNPC1 | |
| SCHEMBL7794802 | 0.74 | ALDH1A1 (0.43) | KMT2AHPGDLMNATSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906268-B1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | AVENTIS PHARMA INC (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6004959-A | HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |