Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | SCN1A | P35498 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7786100 | 0.95 | MAPK1 (0.60) | TSHRCYP2D6USP2MAPK1CYP1A2 | |
| SCHEMBL7795928 | 0.94 | TSHR (0.52) | TSHRCYP2D6USP2MAPK1CYP1A2 | |
| SCHEMBL7786110 | 0.93 | CYP2D6 (0.55) | TSHRCYP2D6USP2MAPK1CYP1A2 | |
| SCHEMBL7796393 | 0.93 | ALDH1A1 (0.52) | TSHRCYP2D6USP2MAPK1CYP1A2 | |
| SCHEMBL7796344 | 0.91 | MAPK1 (0.53) | TSHRCYP2D6USP2MAPK1CYP1A2 | |
| SCHEMBL7792140 | 0.91 | CYP2D6 (0.65) | TSHRCYP2D6USP2CYP1A2ALDH1A1 | |
| SCHEMBL27512822 | 0.90 | MAPK1 (0.49) | TSHRCYP2D6USP2MAPK1CYP1A2 | |
| SCHEMBL7791839 | 0.90 | MAPK1 (0.56) | TSHRCYP2D6USP2MAPK1CYP1A2 | |
| SCHEMBL27493583 | 0.89 | USP2 (0.45) | TSHRCYP2D6USP2MAPK1CYP1A2 | |
| SCHEMBL7792358 | 0.89 | CYP2D6 (0.53) | CYP2D6CYP1A2ALDH1A1KCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906268-B1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | AVENTIS PHARMA INC (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6004959-A | HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |