Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 5/20 | 0.49 |
| ▸ | PYGM | P11217 | 5/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 14/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9024641 | 1.00 | PYGL (0.49) | PYGLPYGMEPHX2RIPK1 | |
| SCHEMBL1269023 | 0.89 | EPHX2 (0.56) | PYGLPYGMEPHX2RIPK1 | |
| SCHEMBL5640963 | 0.89 | EPHX2 (0.56) | PYGLPYGMEPHX2RIPK1 | |
| SCHEMBL1269022 | 0.89 | EPHX2 (0.56) | PYGLPYGMEPHX2RIPK1 | |
| SCHEMBL8332959 | 0.85 | RIPK1 (0.49) | PYGLPYGMRIPK1 | |
| SCHEMBL9025748 | 0.85 | PYGL (0.47) | PYGLPYGMEPHX2RIPK1 | |
| SCHEMBL8329105 | 0.85 | PYGL (0.47) | PYGLPYGMEPHX2RIPK1 | |
| SCHEMBL9025435 | 0.85 | PYGL (0.47) | PYGLPYGMEPHX2RIPK1 | |
| SCHEMBL24859075 | 0.82 | EPHX2 (0.54) | PYGLPYGMEPHX2RIPK1 | |
| SCHEMBL24859076 | 0.82 | EPHX2 (0.54) | PYGLPYGMEPHX2RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0659179-B1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| US-5968924-A | HAVE THE ABILITY TO STIMULATE THE RELEASE OF NATURAL OR ENDOGENOUS GROWTH HORMONE; TREATMENT OF OBESITY, OSTEOPOROSIS | MERCK & CO., INC. (US) | 1999-10-19 | — | — | US | disclosed |
| EP-0513974-B1 | Novel benzo-fused lactams that promote the release of growth hormone | MERCK & CO INC (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5310737-A | Benzo-fused lactams that promote the release of growth hormone | MERCK & CO., INC. (US) | 1994-05-10 | — | — | US | disclosed |
| WO-1994005634-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-03-17 | — | — | WO | disclosed |
| US-5206235-A | Animal growth regulators; stimulants | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0513974-A1 | Novel benzo-fused lactams that promote the release of growth hormone | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992016524-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1992-10-01 | — | — | WO | disclosed |