SCHEMBL7795946

SCHEMBL7795946

CCCOc1cc(OCCCN(CC)CC)c(N)c2c1-c1c(OCCCN(CC)CC)cccc1C2=O

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.41
CYP2D6 P10635 2/20 0.41
SCN1A P35498 2/20 0.41
SCN2A Q99250 2/20 0.41
SCN3A Q9NY46 2/20 0.41
KCNA3 P22001 1/20 0.39
FLT3 P36888 3/20 0.39
CYP3A4 P08684 1/20 0.39
MAOA P21397 1/20 0.39
CYP2C19 P33261 1/20 0.39
KCNH2 Q12809 1/20 0.39
SIGMAR1 Q99720 1/20 0.39
HRH3 Q9Y5N1 1/20 0.39
ALDH1A1 P00352 2/20 0.38
HTR1D P28221 1/20 0.37
HTR1B P28222 1/20 0.37
KDM4E B2RXH2 1/20 0.37
TDP1 Q9NUW8 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7791883 1.00 CYP1A2 (0.41) CYP1A2CYP2D6SCN1ASCN2ASCN3A
SCHEMBL7796600 0.96 CYP1A2 (0.40) CYP1A2CYP2D6SCN1ASCN2ASCN3A
SCHEMBL7794860 0.94 CYP1A2 (0.44) CYP1A2CYP2D6SCN1ASCN2ASCN3A
SCHEMBL7796346 0.94 CYP1A2 (0.44) CYP1A2CYP2D6SCN1ASCN2ASCN3A
SCHEMBL7796463 0.94 CYP1A2 (0.44) CYP1A2CYP2D6SCN1ASCN2ASCN3A
SCHEMBL7796436 0.94 TTR (0.42) KCNA3FLT3MAOAALDH1A1KDM4E
SCHEMBL7794771 0.94 TTR (0.42) KCNA3FLT3MAOAALDH1A1KDM4E
SCHEMBL7796590 0.92 CYP1A2 (0.42) CYP1A2CYP2D6SCN1ASCN2ASCN3A
SCHEMBL7786318 0.92 CYP1A2 (0.42) CYP1A2CYP2D6SCN1ASCN2ASCN3A
SCHEMBL7792112 0.91 ALDH1A1 (0.46) KCNA3FLT3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0906268-B1 ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS AVENTIS PHARMA INC (US) 2001-11-28 EP disclosed
US-6004959-A HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS HOECHST MARION ROUSSEL, INC. (US) 1999-12-21 US disclosed