Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM2 | O94759 | 1/20 | 0.57 |
| ▸ | PARP1 | P09874 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7786369 | 0.99 | TRPM2 (0.59) | TRPM2PARP1TDP1ALDH1A1KMT2A | |
| SCHEMBL7786544 | 0.95 | ALDH1A1 (0.56) | TRPM2PARP1ALDH1A1KMT2AKDM4E | |
| SCHEMBL7786224 | 0.92 | KDM4E (0.53) | TRPM2PARP1TDP1ALDH1A1KMT2A | |
| SCHEMBL7795762 | 0.90 | KDM4E (0.55) | TRPM2PARP1TDP1ALDH1A1KMT2A | |
| SCHEMBL7792581 | 0.88 | USP2 (0.54) | TDP1ALDH1A1KDM4EPOLBCYP1A2 | |
| SCHEMBL5749208 | 0.86 | ALDH1A1 (0.57) | TRPM2PARP1TDP1ALDH1A1KMT2A | |
| SCHEMBL5746735 | 0.85 | ALDH1A1 (0.58) | TRPM2PARP1ALDH1A1KMT2AKDM4E | |
| SCHEMBL7794714 | 0.84 | HRH3 (0.53) | TRPM2PARP1ALDH1A1KDM4EKCNA3 | |
| Hydrochloric Acid SCHEMBL11704257 | 0.84 | ALDH1A1 (0.57) | TRPM2PARP1ALDH1A1KMT2AKDM4E | |
| SCHEMBL7794764 | 0.84 | USP2 (0.58) | TDP1ALDH1A1KDM4EPOLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906268-B1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | AVENTIS PHARMA INC (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6004959-A | HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0906268-A1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997045397-A1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1997-12-04 | — | — | WO | disclosed |