Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7786514 | 0.96 | TSHR (0.46) | TSHRCYP2D6CHEK1HTR2CHTR2B | |
| SCHEMBL7791821 | 0.96 | CHEK1 (0.50) | TSHRCYP2D6CHEK1HTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL7792093 | 0.95 | ALDH1A1 (0.45) | TSHRCYP2D6CHEK1HTR2CHTR2B | |
| SCHEMBL7795660 | 0.95 | KDM4E (0.47) | TSHRCYP2D6CHEK1HTR2CHTR2B | |
| SCHEMBL7786493 | 0.95 | TSHR (0.57) | TSHRCYP2D6CHEK1HTR2BKDM4E | |
| SCHEMBL7792176 | 0.92 | KDM4E (0.50) | TSHRKDM4EALDH1A1MAPK14BRD4 | |
| SCHEMBL7796357 | 0.92 | KDM4E (0.47) | TSHRHTR2BKDM4EALDH1A1MAPK14 | |
| SCHEMBL7786153 | 0.92 | KDM4E (0.47) | TSHRHTR2BKDM4EALDH1A1MAPK14 | |
| SCHEMBL27514211 | 0.92 | ALDH1A1 (0.44) | TSHRCYP2D6CHEK1HTR2CHTR2B | |
| SCHEMBL7795669 | 0.91 | TSHR (0.57) | TSHRCYP2D6CHEK1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906268-B1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | AVENTIS PHARMA INC (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6004959-A | HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |