Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.74 |
| ▸ | GAA | P10253 | 3/20 | 0.74 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.74 |
| ▸ | GLA | P06280 | 1/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.74 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | NQO1 | P15559 | 2/20 | 0.64 |
| ▸ | SHBG | P04278 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | JAK2 | O60674 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | MPI | P34949 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL972802 | 0.90 | KDM4E (0.67) | KDM4EGAAHSD17B3GLANPSR1 | |
| SCHEMBL971942 | 0.85 | KDM4E (1.00) | KDM4EGAAHSD17B3GLANPSR1 | |
| SCHEMBL12204222 | 0.81 | KDM4E (0.70) | KDM4EGAAHSD17B3GLANPSR1 | |
| SCHEMBL9739837 | 0.80 | MAOB (0.48) | KDM4EGAAHSD17B3GLANPSR1 | |
| SCHEMBL18788611 | 0.79 | KDM4E (1.00) | KDM4EGAAHSD17B3GLANPSR1 | |
| SCHEMBL5328894 | 0.78 | KDM4E (0.81) | KDM4EGAAHSD17B3GLANPSR1 | |
| SCHEMBL3786044 | 0.78 | KDM4E (1.00) | KDM4EGAAHSD17B3GLANPSR1 | |
| SCHEMBL6478947 | 0.78 | KDM4E (0.61) | KDM4EGAAGLAALDH1A1POLB | |
| SCHEMBL15917454 | 0.77 | ALDH1A1 (0.74) | KDM4EGAAHSD17B3GLANPSR1 | |
| SCHEMBL14924903 | 0.77 | KDM4E (0.65) | KDM4EGAAHSD17B3GLANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900230-B1 | ESCULETIN DERIVATIVES | IDG UK LTD (GB) | 2001-12-12 | — | — | EP | disclosed |
| US-6287798-B1 | COMPOUND WHICH IS HYDROLYZABLE BY MICROORGANISMS FOR DETECTION IN SAMPLES; FORMS BLACK, INSOLUBLE, NONDIFFUSABLE COMPOUND | IDG (UK) LIMITED (GB) | 2001-09-11 | — | — | US | disclosed |
| US-6008008-A | 6- OR 7-SUBSTITUTED DERIVATIVES WHICH ARE MICROBIALLY HYDROLYZABLE TO FLUORESCENT, IRON CHELATING MOIETIES WHICH ARE NONDIFFUSING IN AGAR AND OTHER AQUEOUS ENVIRONMENTS; FOR DETECTION OF MICROORGANISMS | IDG (UK) LIMITED (GB) | 1999-12-28 | — | — | US | disclosed |
| EP-0900230-A2 | ESCULETIN DERIVATIVES | IDG (UK) Limited (GB) | 1999-03-10 | — | — | EP | disclosed |
| WO-1997041138-A2 | ESCULETIN DERIVATIVES | IDG (UK) LIMITED (GB) | 1997-11-06 | — | — | WO | disclosed |