SCHEMBL7797783

SCHEMBL7797783

NC(N)=NC(=O)c1cc(I)c(O)c(I)c1Cl

nearest known ligand 0.45

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SLC9A1 P19634 5/20 0.45
PLAU P00749 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7799870 0.98 SLC9A1 (0.44) SLC9A1PLAU
SCHEMBL1043966 0.75 TP53 (0.45)
SCHEMBL7797853 0.75 SLC9A1 (0.50) SLC9A1PLAU
Hydrochloric Acid SCHEMBL7791939 0.74 SLC9A1 (0.49) SLC9A1PLAU
SCHEMBL7797776 0.72 PLAU (0.41) PLAU
SCHEMBL8430500 0.71 SLC9A1 (0.42) SLC9A1PLAU
Hydrochloric Acid SCHEMBL7799865 0.71 PLAU (0.40) PLAU
SCHEMBL7952054 0.70 CFTR (0.42)
Hydrochloric Acid SCHEMBL8336406 0.70 SLC9A1 (0.41) SLC9A1PLAU
SCHEMBL10963400 0.67 TP53 (0.40) PLAU

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0794172-B1 Orthosubstituted benzoylguanidines HOECHST AG (DE) 2001-10-24 EP claimed
US-6262123-B1 AS ANTIARRHYTHMIC AGENTS HAVING CARDIOPROTECTIVE COMPONENT, FOR PROPHYLAXIS AND TREATMENT OF INFARCTION AND ANGINA PECTORIS; FOR INHIBITION OF PATHOPHYSIOLOGICAL PROCESSES ASSOCIATED WITH GENESIS OF ISCHEMICALLY INDUCED DAMAGE AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2001-07-17 US claimed