SCHEMBL7797891

SCHEMBL7797891

NCCSc1ccc(C(F)(F)F)cn1

nearest known ligand 0.56

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.56
L3MBTL1 Q9Y468 1/20 0.53
PKM P14618 1/20 0.53
KDM4E B2RXH2 1/20 0.48
RECQL P46063 1/20 0.46
HSD17B3 P37058 1/20 0.43
RAB9A P51151 2/20 0.43
TAAR1 Q96RJ0 2/20 0.43
HRH1 P35367 1/20 0.42
HRH4 Q9H3N8 1/20 0.42
KMT2A Q03164 1/20 0.41
MAPT P10636 1/20 0.40
KIF11 P52732 1/20 0.40
DDB1 Q16531 1/20 0.39
CRBN Q96SW2 1/20 0.39
MAOB P27338 1/20 0.39
DAO P14920 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4492296 0.83 ALDH1A1 (0.56) ALDH1A1L3MBTL1PKMKDM4ERECQL
SCHEMBL20381801 0.83 ALDH1A1 (0.57) ALDH1A1L3MBTL1PKMKDM4ERECQL
SCHEMBL2585379 0.83 ALDH1A1 (0.56) ALDH1A1L3MBTL1PKMKDM4ERECQL
SCHEMBL16592116 0.80 ALDH1A1 (0.54) ALDH1A1L3MBTL1PKMKDM4ERECQL
SCHEMBL14234544 0.79 ALDH1A1 (0.56) ALDH1A1L3MBTL1PKMKDM4ERECQL
SCHEMBL14350432 0.79 ALDH1A1 (0.52) ALDH1A1L3MBTL1PKMKDM4ERECQL
SCHEMBL7023026 0.76 ALDH1A1 (0.50) ALDH1A1L3MBTL1PKMKDM4ERECQL
SCHEMBL1662231 0.76 PIK3CD (0.43) ALDH1A1L3MBTL1PKMKDM4ERECQL
SCHEMBL5717582 0.76 ALDH1A1 (0.61) ALDH1A1L3MBTL1PKMKDM4ERECQL
SCHEMBL30697702 0.75 ALDH1A1 (0.49) ALDH1A1L3MBTL1PKMKDM4ERECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0796847-B1 Pyridine derivative, anti-ulcer drug, and antibacterial drug SHISEIDO CO LTD (JP) 2001-11-28 EP disclosed
US-6017937-A BACTERICIDE AGAINST HELICOBACTER PYROLI; INHIBITING ACID SECRETION IN STOMACH OF MAN OR MAMMALS, PREVENTING OR CURING ULCER SHISEIDO CO., LTD. (JP) 2000-01-25 US disclosed
US-5859032-A HAVING ANTIBACTERIAL ACTIVITY AGAINST HELICOBACTER PYLORI SHISEIDO CO., LTD. (JP) 1999-01-12 US disclosed
EP-0796847-A1 Pyridine derivative, anti-ulcer drug, and antibacterial drug SHISEIDO COMPANY LIMITED (JP) 1997-09-24 EP disclosed