SCHEMBL7797901

SCHEMBL7797901

C=CC(=O)C(OC(F)(F)F)c1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.38
CTSD P07339 1/20 0.37
AKT1 P31749 1/20 0.36
ALDH1A1 P00352 2/20 0.36
CYP3A4 P08684 1/20 0.36
TDP1 Q9NUW8 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
TACR1 P25103 2/20 0.35
GAA P10253 1/20 0.35
CYP2D6 P10635 1/20 0.34
SRC P12931 1/20 0.34
HDAC3 O15379 1/20 0.34
HDAC4 P56524 1/20 0.34
HDAC1 Q13547 1/20 0.34
HDAC7 Q8WUI4 1/20 0.34
HDAC2 Q92769 1/20 0.34
HDAC10 Q969S8 1/20 0.34
HDAC11 Q96DB2 1/20 0.34
HDAC8 Q9BY41 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2529459 0.80 CYP2D6 (0.45) ALDH1A1CYP3A4CYP2D6SRCLMNA
SCHEMBL17724521 0.80 CYP2D6 (0.45) ALDH1A1CYP3A4CYP2D6SRCLMNA
Hydrochloric Acid SCHEMBL2530813 0.79 CYP2D6 (0.43) ALDH1A1CYP3A4CYP2D6SRCLMNA
SCHEMBL6963705 0.79 ALDH1A1 (0.40) CTSDALDH1A1CYP3A4GAACYP2D6
SCHEMBL27715833 0.77 PPARG (0.39) CTSDALDH1A1CYP3A4GAACYP2D6
SCHEMBL3458611 0.77 EPHX1 (0.43) CTSDALDH1A1CYP3A4GAACYP2D6
SCHEMBL4658943 0.73 POLB (0.56) ALDH1A1L3MBTL1TACR1GAALMNA
SCHEMBL19312090 0.72 MMP8 (0.49) ALDH1A1TDP1GAALMNAKMT2A
SCHEMBL17724435 0.72 MMP8 (0.49) ALDH1A1TDP1GAALMNAKMT2A
SCHEMBL13517797 0.72 TDP1 (0.52) CYP2C19CTSDAKT1TDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1115693-A1 SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL $i(TERTIARY)-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY Monsanto Company (US) 2001-07-18 EP disclosed
WO-2000018721-A1 SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL TERTIARY-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY MONSANTO COMPANY (US) 2000-04-06 WO disclosed