Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.86 |
| ▸ | POLB | P06746 | 2/20 | 0.86 |
| ▸ | APEX1 | P27695 | 1/20 | 0.86 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.86 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | PLA2G4B | P0C869 | 6/20 | 0.52 |
| ▸ | RARB | P10826 | 3/20 | 0.50 |
| ▸ | CASP6 | P55212 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2034725 | 0.94 | HTT (0.97) | HTTPOLBAPEX1TDP1PKM | |
| SCHEMBL1309117 | 0.93 | HTT (1.00) | HTTPOLBAPEX1TDP1PKM | |
| SCHEMBL8962574 | 0.93 | HTT (1.00) | HTTPOLBAPEX1TDP1PKM | |
| SCHEMBL10428187 | 0.93 | HTT (1.00) | HTTPOLBAPEX1TDP1PKM | |
| SCHEMBL9952684 | 0.93 | HTT (1.00) | HTTPOLBAPEX1TDP1PKM | |
| SCHEMBL8682933 | 0.93 | HTT (1.00) | HTTPOLBAPEX1TDP1PKM | |
| SCHEMBL10428461 | 0.93 | HTT (1.00) | HTTPOLBAPEX1TDP1PKM | |
| SCHEMBL8678901 | 0.93 | HTT (1.00) | HTTPOLBAPEX1TDP1PKM | |
| SCHEMBL4577427 | 0.93 | TDP1 (0.73) | HTTPOLBAPEX1TDP1PKM | |
| Biphenyl SCHEMBL1493814 | 0.92 | HTT (0.87) | HTTPOLBAPEX1TDP1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0887399-B1 | Silicones having a low glass transition temperature | CONSORTIUM ELEKTROCHEM IND (DE) | 2001-11-28 | — | — | EP | disclosed |
| US-6040411-A | Low glass temperature organosiloxanes | CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) | 2000-03-21 | — | — | US | disclosed |
| EP-0887399-A1 | Silicones having a low glass transition temperature | Consortium für elektrochemische Industrie GmbH (DE) | 1998-12-30 | — | — | EP | disclosed |