SCHEMBL7798448

SCHEMBL7798448

O=S(=O)(c1c(Cl)nc(Br)n1-c1c(Cl)cc(C(F)(F)F)cc1Cl)C(F)F

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA2 P47869 11/20 0.36
GABRB2 P47870 11/20 0.36
GABRB3 P28472 9/20 0.36
GABRP O00591 5/20 0.36
GABRD O14764 5/20 0.36
GABRA1 P14867 5/20 0.36
GABRB1 P18505 5/20 0.36
GABRG2 P18507 5/20 0.36
GABRA5 P31644 5/20 0.36
GABRA3 P34903 5/20 0.36
GABRA4 P48169 5/20 0.36
GABRE P78334 5/20 0.36
GABRA6 Q16445 5/20 0.36
GABRG1 Q8N1C3 5/20 0.36
GABRG3 Q99928 5/20 0.36
GABRQ Q9UN88 5/20 0.36
ABL1 P00519 1/20 0.33
BCR P11274 1/20 0.33
NR1I2 O75469 1/20 0.32
LMNA P02545 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7800351 0.89 GABRB3 (0.39) GABRA2GABRB2GABRB3GABRPGABRD
SCHEMBL9119130 0.87 GABRA2 (0.37) GABRA2GABRB2GABRB3GABRPGABRD
SCHEMBL9120944 0.85 GABRA2 (0.36) GABRA2GABRB2GABRB3GABRPGABRD
SCHEMBL9119928 0.74 GABRA2 (0.38) GABRA2GABRB2GABRB3GABRPGABRD
SCHEMBL9121513 0.72 GABRA2 (0.34) GABRA2GABRB2GABRB3GABRPGABRD
SCHEMBL9171855 0.68 GABRB3 (0.54) GABRA2GABRB2GABRB3GABRPGABRD
SCHEMBL7798589 0.65 EPAS1 (0.33)
SCHEMBL7792819 0.64 GABRA2 (0.49) GABRA2GABRB2GABRB3GABRPGABRD
SCHEMBL7798451 0.63 GABRA2 (0.36) GABRA2GABRB2GABRB3GABRPGABRD
SCHEMBL9119203 0.63 GABRA2 (0.36) GABRA2GABRB2GABRB3GABRPGABRD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0396427-B1 Pesticidal 1-arylimidazoles RHONE POULENC AGROCHIMIE (FR) 1995-09-13 EP claimed
EP-0396427-A1 Pesticidal 1-arylimidazoles RHONE-POULENC AGROCHIMIE (FR) 1990-11-07 EP claimed
EP-0484165-B1 Pesticidal 1-arylimidazoles AVENTIS CROPSCIENCE SA (FR) 2001-08-16 EP disclosed
EP-0396427-B1 Pesticidal 1-arylimidazoles RHONE POULENC AGROCHIMIE (FR) 1995-09-13 EP disclosed
US-5223525-A Pesticidal 1-arylimidazoles RHONE-POULENC AG COMPANY (US) 1993-06-29 US disclosed
EP-0484165-A1 Pesticidal 1-arylimidazoles RHONE-POULENC AGROCHIMIE (FR) 1992-05-06 EP disclosed
EP-0396427-A1 Pesticidal 1-arylimidazoles RHONE-POULENC AGROCHIMIE (FR) 1990-11-07 EP disclosed