Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.56 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
| ▸ | AGER | Q15109 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL940062 | 1.00 | LMNA (0.59) | LMNACYP2D6L3MBTL1ADRB2ADRB1 | |
| SCHEMBL1496636 | 0.93 | LMNA (0.52) | LMNACYP2D6L3MBTL1ADRB2ADRB1 | |
| SCHEMBL267463 | 0.87 | LMNA (0.68) | LMNACYP2D6L3MBTL1ADRB2ADRB1 | |
| SCHEMBL14901597 | 0.83 | ALDH1A1 (0.49) | LMNACYP2D6KDM4EMAPTHTT | |
| SCHEMBL14901593 | 0.83 | MAPT (0.47) | LMNACYP2D6KDM4EMAPTHTT | |
| SCHEMBL1496796 | 0.82 | MAPK1 (0.59) | LMNAKDM4EMAPTHTTSMN1; SMN2 | |
| SCHEMBL4619478 | 0.81 | TSHR (0.62) | LMNACYP2D6L3MBTL1ADRB2ADRB1 | |
| SCHEMBL6480727 | 0.81 | TSHR (0.62) | LMNACYP2D6L3MBTL1ADRB2ADRB1 | |
| SCHEMBL117951 | 0.81 | TSHR (0.62) | LMNACYP2D6L3MBTL1ADRB2ADRB1 | |
| SCHEMBL11400908 | 0.81 | LMNA (0.61) | LMNACYP2D6L3MBTL1ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104395-A1 | STEREOSELECTIVE RING OPENING REACTIONS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2001-06-06 | — | — | EP | disclosed |
| WO-2000009463-A1 | STEREOSELECTIVE RING OPENING REACTIONS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2000-02-24 | — | — | WO | disclosed |