Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.45 |
| ▸ | DPP4 | P27487 | 2/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL7798457 | 1.00 | DPP8 (0.45) | DPP8DPP4DPP7KDM4EPOLB | |
| Ornithine Aketoglutarate SCHEMBL7801491 | 0.98 | KDM4E (0.42) | DPP8DPP4DPP7KDM4EPOLB | |
| Ornithine SCHEMBL7801486 | 0.98 | KDM4E (0.42) | DPP8DPP4DPP7KDM4EPOLB | |
| Lysine SCHEMBL7802939 | 0.91 | DPP8 (0.41) | DPP8DPP4DPP7LTA4HMMP2 | |
| Lysine SCHEMBL7793380 | 0.91 | DPP8 (0.41) | DPP8DPP4DPP7LTA4HMMP2 | |
| Lysine SCHEMBL7793383 | 0.91 | DPP8 (0.41) | DPP8DPP4DPP7LTA4HMMP2 | |
| Lysine SCHEMBL7800261 | 0.91 | KDM4E (0.48) | DPP8DPP4DPP7KDM4EPOLB | |
| Lysine SCHEMBL7802577 | 0.91 | ENPP2 (0.41) | DPP8DPP4DPP7KDM4EPOLB | |
| Lysine SCHEMBL7802575 | 0.91 | ENPP2 (0.41) | DPP8DPP4DPP7KDM4EPOLB | |
| Lysine SCHEMBL7802667 | 0.91 | DPP8 (0.39) | DPP8DPP4DPP7KDM4ELTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076649-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 2001-02-21 | — | — | EP | disclosed |
| WO-1999055679-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 1999-11-04 | — | — | WO | disclosed |