Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 7/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL7802577 | 1.00 | ENPP2 (0.41) | ENPP2EPHX2KDM4EPOLBCPB2 | |
| Ornithine SCHEMBL7801608 | 0.98 | ENPP2 (0.41) | ENPP2EPHX2KDM4EPOLBMTNR1A | |
| Ornithine Aketoglutarate SCHEMBL7801606 | 0.98 | ENPP2 (0.41) | ENPP2EPHX2KDM4EPOLBMTNR1A | |
| Lysine SCHEMBL7800240 | 0.92 | ENPP2 (0.42) | ENPP2LTA4HALDH1A1MAPT | |
| Lysine SCHEMBL7800242 | 0.92 | ENPP2 (0.42) | ENPP2LTA4HALDH1A1MAPT | |
| Lysine SCHEMBL8039364 | 0.92 | KDM4E (0.45) | KDM4EPOLBMTNR1AMTNR1BLTA4H | |
| P-Anisic Acid SCHEMBL7802648 | 0.91 | EPHX2 (0.41) | ENPP2EPHX2KDM4EPOLBCPB2 | |
| Lysine SCHEMBL7801581 | 0.91 | ENPP2 (0.42) | ENPP2LTA4HSMN1; SMN2 | |
| P-Anisic Acid SCHEMBL7802650 | 0.91 | EPHX2 (0.41) | ENPP2EPHX2KDM4EPOLBCPB2 | |
| Lysine SCHEMBL7801579 | 0.91 | ENPP2 (0.42) | ENPP2LTA4HSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076649-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 2001-02-21 | — | — | EP | disclosed |
| WO-1999055679-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 1999-11-04 | — | — | WO | disclosed |