Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA4 | P22748 | 2/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.38 |
| ▸ | ADH1B | P00325 | 1/20 | 0.34 |
| ▸ | ADH1C | P00326 | 1/20 | 0.34 |
| ▸ | ADH1A | P07327 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25887063 | 1.00 | CA1 (0.39) | CA1CA2CA4SLC18A3ADH1B | |
| SCHEMBL8989800 | 1.00 | CA1 (0.39) | CA1CA2CA4SLC18A3ADH1B | |
| SCHEMBL6658499 | 0.82 | ADH1B (0.41) | ADH1BADH1CADH1A | |
| SCHEMBL17426952 | 0.82 | ADH1B (0.41) | ADH1BADH1CADH1A | |
| SCHEMBL17426973 | 0.82 | ADH1B (0.41) | ADH1BADH1CADH1A | |
| Hydrochloric Acid SCHEMBL6657586 | 0.77 | ADH1B (0.38) | ADH1BADH1CADH1A | |
| SCHEMBL23275886 | 0.72 | — | — | |
| SCHEMBL3087522 | 0.72 | SLC18A3 (0.46) | CA1CA2CA4SLC18A3KCNA5 | |
| SCHEMBL20095858 | 0.72 | — | — | |
| SCHEMBL3081603 | 0.72 | SLC18A3 (0.46) | CA1CA2CA4SLC18A3KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0720605-B1 | AMINOCYCLOHEXYLESTERS AND USES THEREOF | UNIV BRITISH COLUMBIA (CA) | 2001-12-19 | — | — | EP | disclosed |
| US-6174879-B1 | BLOCKING SODIUM AND POTASSIUM ION CHANNELS IN VIVO AND IN VITRO; ANTIARRHYTHMIA AGENTS | UNIVERSITY OF BRITISH COLUMBIA (CA) | 2001-01-16 | — | — | US | disclosed |
| US-5885984-A | BLOCKADE OF ION CHANNELS AND THE TREATMENT OF ARRHYTHMIAS. | UNIVERSITY OF BRITISH COLUMBIA (CA) | 1999-03-23 | — | — | US | disclosed |
| US-5637583-A | ANTIARRHYTHMIA AGENTS | UNIVERSITY OF BRITISH COLUMBIA (CA) | 1997-06-10 | — | — | US | disclosed |